Antigen binding proteins targeting an hla-restricted kk-lc-1 peptide
AssigneeCdr-Life AG
InventorsFabian Bert Scheifele, Anna Maria Sobieraj, Nagjie Laila Alijaj, Stephanie Jungmichel, Philip Knobel, Leonardo Borras
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Abstract
Described herein are antigen binding proteins targeting KK-LC-1 derived peptide-MHCs (pMHCs). Also described are multispecific antigen binding proteins comprising an antigen binding domain with specificity to CD3, and at least one target peptide binding domain. Methods of treatment with the same are also described.
Claims32
An antigen binding protein which specifically binds to a major histocompatibility complex (MHC)-displayed NTDNNLAVY (SEQ ID NO:
- 54), wherein the antigen binding protein comprises:
- (a) an antibody heavy chain variable (VH) domain comprising an HCDR1 amino acid sequence of SSYYYMC (SEQ ID NO:
- 25), an HCDR2 amino acid sequence of CIYAGSSGSTYYASWAKG (SEQ ID NO:
- 26), and an HCDR3 amino acid sequence of GAGYGNGGHSL (SEQ ID NO:
- 27);
- and
- (b) an antibody light chain variable (VL) domain comprising an LCDR1 amino acid sequence of RASKNIYNSLA (SEQ ID NO:
- 28), an LCDR2 amino acid sequence of GASNLES (SEQ ID NO:
- 29), and an LCDR3 amino acid sequence of QATYYGHDNIGGA (SEQ ID NO:
- 30.
An antigen binding protein which specifically binds to a major histocompatibility complex (MHC)-displayed NTDNNLAVY (SEQ ID NO:
- 54), wherein the antigen binding protein comprises:
- (a) an antibody heavy chain variable (VH) domain comprising or consisting of the amino acid sequence that is at least about 90%, 95%, 96%, 97%, 98%, 99% or 100% identical to SEQ ID NO:
- 31;
- and
- (b) an antibody light chain variable (VL) domain comprising or consisting of the amino acid sequence that is at least about 90%, 95%, 96%, 97%, 98%, 99% or 100% identical to SEQ ID NO:
- 32.
6-10. (canceled)
12-13. (canceled)
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(canceled)
A multispecific antigen binding protein that specifically binds to a major histocompatibility complex (MHC)-displayed NTDNNLAVY (SEQ ID NO:
- 54) and an immune cell, comprising
- (1) a first and optionally a second antigen binding domain that binds to the MHC-displayed NTDNNLAVY (SEQ ID NO:
- 54), comprising:
- (a) an antibody heavy chain variable (VH) domain comprising an HCDR1 amino acid sequence of SSYYYMC (SEQ ID NO:
- 25), an HCDR2 amino acid sequence of CIYAGSSGSTYYASWAKG (SEQ ID NO:
- 26), and an HCDR3 amino acid sequence of GAGYGNGGHSL (SEQ ID NO:
- 27);
- and
- (b) an antibody light chain variable (VL) domain comprising an LCDR1 amino acid sequence of RASKNIYNSLA (SEQ ID NO:
- 28), an LCDR2 amino acid sequence of GASNLES (SEQ ID NO:
- 29), and an LCDR3 amino acid sequence of QATYYGHDNIGGA (SEQ ID NO:
- 30);
- and
- (2) an immune cell binding domain.
24-31. (canceled)
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55-58. (canceled)
60-66. (canceled)
Dependencies are inferred from the claim text.