Polypeptide adjuvants and uses thereof
AssigneeBoard of Regents, The University of Texas System
InventorsYon Son Betty KIM, DaeYong LEE, Wen JIANG, Kristin HUNTOON
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Abstract
The present disclosure provides polypeptide-based adjuvants that are capable of activating the innate immune system and are capable of generating targeted and precise immunogenicity. Also provided are compositions, pharmaceutical compositions, and vaccines comprising or using the polypeptide-based adjuvants, as well as methods of treating cancer or including or enhancing an immune response using such polypeptide-based adjuvants.
Claims54
A cationic polypeptide-based adjuvant comprising a poly-lysine peptide conjugated to at least one amine containing building block.
A polypeptide-based adjuvant comprising the structure of Formula 1:
- wherein:
- a. K is a poly-lysine peptide;
- b. A is an amine containing building block, an immunogenic agent, an imaging agent, a therapeutic agent, a stabilizing agent, targeting agent, CH3 or is absent;
- c. X is CH2 or —CH2CH2O;
- d. L is a linker;
- wherein n is an integer from 1 to 10, and
- is an integer from 0 to 1.
Dependencies are inferred from the claim text.