Compositions and methods for treating tendon and bone injuries
AssigneesThe United States Government as represented by the Department of Veterans Affairs, University of Southern California, The Regents of the University of California
InventorsCharles Edward McKenna, Thomas Kremen
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Abstract
In one aspect, the invention relates to synthetic molecules, compositions and pharmaceutical compositions, which are useful for delivering a bioactive moiety to a site of injury. Also disclosed are methods of treating a tendon injury, methods of treating a fracture, methods of treating a bone stress injury, methods of enhancing incorporation of allograft tissues, methods of promoting repair or regeneration of enthesis tissue during or after an orthopedic surgical procedure, and method of treating osteoporosis, osteoarthritis and/or cartilage defects using the disclosed molecules, compositions and pharmaceutical compositions.
Claims62
A molecule comprising:
- i) a bioactive moiety;
- ii) a cleavable linker;
- and
- iii) a bisphosphonate (BP) moiety;
- wherein the BP moiety has a P-C-P structure, and
- wherein the cleavable linker links the bioactive moiety to the BP moiety.
A method of targeting a molecule to a site of injury to a subject in need thereof, comprising administering a molecule comprising:
- i) a bioactive moiety;
- ii) a cleavable linker;
- and
- iii) a bisphosphonate (BP) moiety;
- wherein the BP moiety has a P-C-P structure, and
- wherein the cleavable linker links the bioactive moiety to the BP moiety.
A method of treating a tendon injury, fracture and/or bone stress injury and/or promoting soft tissue to bone healing to a subject in need thereof, comprising administering a molecule comprising:
- i) a bioactive moiety;
- ii) a cleavable linker;
- and
- iii) a bisphosphonate (BP) moiety;
- wherein the BP moiety has a PCP structure, and
- wherein the cleavable linker links the bioactive moiety to the BP moiety.
A method of enhancing incorporation of allograft tissues or promoting repair of enthesis during or after an orthopedic surgical procedure to a subject in need thereof comprising administering a molecule comprising:
- i) a bioactive moiety;
- ii) a cleavable linker;
- and
- iii) a bisphosphonate (BP) moiety;
- wherein the BP moiety has a PCP structure, and
- wherein the cleavable linker links the bioactive moiety to the BP moiety.
A method of treating osteoporosis, osteoarthritis and/or cartilage defects in a subject in need thereof, comprising administering a molecule comprising:
- i) a bioactive moiety;
- ii) a cleavable linker;
- and
- iii) a bisphosphonate (BP) moiety;
- wherein the BP moiety has a PCP structure, and
- wherein the cleavable linker links the bioactive moiety to the BP moiety.
Dependencies are inferred from the claim text.