Formulations for the Suprachoroidal Space of an Eye and Methods
AssigneesEmory University, Georgia Tech Research Corporation
InventorsMark R. Prausnitz, Bryce Chiang
Life of this patent
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Abstract
Provided herein are fluid formulations for administration to a suprachoroidal space of an eye of a patient. The fluid formulations may include a pharmaceutical agent, a binding molecule, or a combination thereof. The pharmaceutical agent and the binding molecule may be bonded to each other covalently, non-covalently, or a combination thereof. The pharmaceutical agent may be configured to bond to an ocular tissue. The binding molecule may be configured to bond to an ocular tissue. Methods of administering the fluid formulations, methods of expanding a suprachoroidal space, and methods of reducing the minimum force to separate the sclera and choroid are provided.
Claims20
A method of expanding a suprachoroidal space of an eye, the method comprising:
- inserting a microneedle into the eye at an insertion site;
- and then
- infusing through the microneedle into the suprachoroidal space a first liquid formulation having a volume and a viscosity sufficient to expand at least a portion of the suprachoroidal space to a thickness of about 500 μm to about 3.0 mm for at least two hours after the infusing.
A method of expanding a suprachoroidal space of an eye, the method comprising:
- inserting a microneedle into the eye at an insertion site;
- and then
- infusing through the microneedle into the suprachoroidal space a first liquid formulation having a volume and a viscosity sufficient to expand at least a portion of the suprachoroidal space to a thickness of about 500 μm to about 3.0 mm for a period exceeding 24 hours after the infusing;
- wherein the first liquid formulation is configured to solidify, form a crosslinked hydrogel, or a combination thereof in the suprachoroidal space.
Dependencies are inferred from the claim text.