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US 2026/0284192 A1Published application
Methods and materials for treating cancer
AssigneeMayo Foundation for Medical Education and Research
InventorsTimothy J. Kottke, Laura Evgin, Richard G. Vile
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Abstract
This document relates to methods and materials involved in treating cancer. For example, methods and materials for using (a) T cells (e.g., chimeric antigen receptor (CAR) T cells), (b) one or more antigenic compositions (e.g., one or more compositions including one or more antigens), and (c) one or more immune checkpoint inhibitors to treat a mammal (e.g., a human) having cancer are provided.
Claims30
A method for treating a mammal having cancer, wherein said method comprises:
- (a) administering a population of T cells with different endogenous T cell receptors (TCRs) to said mammal, wherein said T cells comprise a chimeric antigen receptor (CAR) that targets said cancer;
- (b) administering a first antigenic composition to said mammal, wherein at least some of said T cells of said population form memory T cells within said mammal, wherein said memory T cells comprise said CAR and an endogenous TCR specific for an antigen of said first antigenic composition;
- (c) administering a second antigenic composition comprising said antigen to said mammal, wherein said memory T cells are stimulated via their endogenous TCRs to form effector T cells comprising said CAR, and wherein said effector T cells reduce the number of cancer cells within said mammal;
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- (d) administering an immune checkpoint inhibitor to said mammal.
2 more elements
Dependencies are inferred from the claim text.