Vaccine with reduced anti-vector antigenicity
OwnerReinhard FASSLER, Wolfgang NEUBERT +2inventors
InventorsReinhard FASSLER, Wolfgang NEUBERT, Marian WIEGAND, Ulrich M. LAUER
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Abstract
The present invention relates to a recombinant replication-deficient or replication competent negative-strand RNA virus, (i) capable of displaying a heterologous antigen on the surface, and thus capable of inducing mucosal immunity in host, (ii) after entering a host cell, producing a heterologous antigen, thereby improving immune response of the host to the antigen, and (iii) having a reduced anti-vector antigenicity in comparison to the wildtype vector, thus reducing an immune response of the host to the vector.
Claims21
A negative-strand RNA virus, comprising in its genome:
- (a) a nucleotide sequence encoding a P polypeptide, wherein
- (i) the P polypeptide is modified in comparison to a respective wildtype P polypeptide, said modification providing a replication-deficient negative-strand RNA virus, or
- (ii) the P polypeptide has the same function in the viral replication cycle as a respective wildtype P polypeptide, or is a wildtype P polypeptide with the sequence SEQ ID NO:
- 002, providing a replication-competent negative-strand RNA virus;
- and
- (b) at least one nucleotide sequence encoding at least one heterologous polypeptide, wherein
- the at least one heterologous polypeptide is displayed on the surface of the virus particle, wherein the heterologous polypeptide comprises a viral antigen, and wherein the viral antigen and the negative-stranded RNA virus are selected from viruses of different families.
(canceled)
Dependencies are inferred from the claim text.