Hiv vaccine
OwnerValentin LE DOUCE, Ekaterina ESAULOVA +5inventors
InventorsValentin LE DOUCE, Ekaterina ESAULOVA, Daphne KAXIRAS, Michael Steven ROONEY, Theresa ADDONA, Ugur SAHIN, Gaurav GAIHA
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Abstract
The present invention concerns compositions comprising an RNA molecule, wherein the RNA molecule comprises an expression cassette encoding an immunogenic peptide, which peptide comprises at least two fragments, wherein each fragment comprises at least one epitope, wherein the epitope is derived from an amino acid sequence encoded by the human immunodeficiency virus (HIV) and medical preparations comprising such compositions. Furthermore, the invention concerns methods for preventing or treating HIV.
Claims149
A composition comprising an RNA molecule, wherein the RNA molecule comprises an expression cassette encoding an immunogenic peptide, which peptide comprises at least two fragments, wherein each fragment comprises at least one epitope, wherein the epitope is derived from an amino acid sequence encoded by the human immunodeficiency virus (HIV) and wherein the epitope is comprised within or comprises a sequence selected from any one of SEQ ID NOs:
- 1 to 148 and 198 to 202 or a variant thereof.
A method for preventing HIV infection in a subject, said method comprising dissolving the composition according to 116 into a suitable liquid pharmaceutical solution forming a solution for administration and administering the solution for administration to the subject.
A method for treating HIV infection in a HIV-positive subject, said method comprising dissolving the composition according to 116 into a suitable liquid pharmaceutical solution forming a solution for administration and administering the solution for administration to the subject.
A method for treating or preventing HIV infection comprising administering a first RNA molecule and a second RNA molecule to a subject,
- wherein the first RNA molecule comprises a nucleotide sequence encoding a first peptide, which first peptide comprises the amino acid sequences of
- a) SEQ ID NOs:
- 60, 103, 98, 149, 2, 150, 142, 86, 1, 141, 151, 152, 130, 153, 154, 155, 156, 157, 158, 4, 159, 160, 161, 162, 35, 28, 163, 164, 165, 166, 87, 167, and 85 or
- b) SEQ ID NOs:
- 60, 103, 98, 149, 2, 150, 142, 86, 1, 141, 151, 152, 199, 153, 154, 155, 156, 157, 158, 4, 159, 160, 161, 162, 35, 28, 203, 164, 165, 166, 87, 167, and 85;
- and
- wherein the second RNA molecule comprises a nucleotide sequence encoding a second peptide, which second peptide comprises the amino acid sequences of
- c) SEQ ID NOs:
- 98, 125, 29, 85, 168, 35, 150, 149, 169, 87, 57, 3, 170, 171, 172, 99, 131, 173, 174, 175, 104, 176, 61, 177, 178, 179, 5, 180, 181, 1, 182, and 140 or
- d) SEQ ID NOs:
- 98, 125, 29, 85, 168, 35, 150, 149, 169, 87, 57, 3, 170, 171, 172, 99, 131, 173, 174, 175, 104, 176, 61, 177, 204, 179, 5, 180, 181, 1, 182, and 140.
Dependencies are inferred from the claim text.