Influenza virus vaccines

An immunogenic composition comprising:

• (a) a first hemagglutinin (HA) antigen or a first nucleic acid, suitably mRNA, encoding the first HA antigen wherein the first HA antigen is derived from a strain of subtype H3 of Influenza A virus;
• and
• (b) a second HA antigen or a second nucleic acid, suitably mRNA, encoding the second HA antigen wherein the second HA antigen is derived from a strain of subtype H1 of Influenza A virus,
• wherein the ratio of (a):(b) is comprised between 1.5:1 and 20:1, optionally between 1.5:1 and 5:1.

An immunogenic composition comprising:

• (a) a first mRNA encoding a HA of a strain of subtype H3 of Influenza A virus;
• (b) a second mRNA encoding a HA of a strain of subtype H1 of Influenza A virus;
• (c1) a third mRNA encoding a HA of a first strain of Influenza B virus;
• and
• (c2) optionally, a fourth mRNA encoding a HA of a second strain of Influenza B virus,
• wherein the ratio of (a):(b):
• (c1):
• (c2) is comprised between 1.5:1:1:1 and 20:1:1:1, optionally between 1.5:1:1:1 and 5:1:1:1.