Rna for preventing or treating tuberculosis
OwnerLouis Simon ATES, Charles Lefco DULBERGER +4inventors
InventorsLouis Simon ATES, Charles Lefco DULBERGER, Julia UEBELE, Babak JAVID, Paul Anthony MACARY, Sandro HOFFMANN
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Abstract
The disclosure provides agents and methods for preventing or treating tuberculosis using RNA. The RNA encoding antigens of Mycobacterium tuberculosis, immunogenic variants or fragments thereof is formulated and administered in a way that the antigens, variants or fragments are produced by cells of a subject.
Claims73
RNA molecule comprising a sequence encoding at least one full-length antigen or antigen fragment representing at least one Mycobacterium tuberculosis antigen or immunogenic variant thereof, wherein the Mycobacterium tuberculosis antigen is selected from the group of LpqH and PstS1.
Dependencies are inferred from the claim text.