Peptide conjugated particles
AssigneeNorthwestern University
InventorsLonnie D. Shea, Stephen Miller, Jonathan Woon Teck Yap, Daniel R. Getts, Derrick McCarthy
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Abstract
The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).
Claims20
1-91. (canceled)
A composition comprising surface functionalized biodegradable particles comprising one or more encapsulated antigens or antigenic epitopes thereof, wherein the particles have a negative zeta potential of about −100 mV to about −30 mV, and wherein the antigen is associated with myasthenia gravis (MG).
A composition comprising surface functionalized biodegradable poly(lactide-co-glycolide) (PLG) particles comprising one or more encapsulated antigens or antigenic epitopes thereof associated with myasthenia gravis (MG), wherein the PLG particles have a diameter of about 200 nm to about 2000 nm and a zeta potential of about −30 mv to about −80 mv.
A method of inducing antigen-specific tolerance in a subject having myasthenia gravis (MG) comprising administering to the subject an effective amount of a composition comprising surface functionalized biodegradable particles comprising one or more encapsulated antigens or antigenic epitopes thereof, wherein the particles have a negative zeta potential of about −100 mV to about −30 mV, and wherein the antigen is associated with myasthenia gravis (MG).
Dependencies are inferred from the claim text.