Targeting the igf-1 pathway to extend organ lifespan
AssigneeThe Regents of the University of Michigan
InventorsAbhijit S. Naik, Roger C. Wiggins
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Abstract
Provided herein are compositions and methods for extending organ lifespan, including extending the lifespan of a transplanted organ. The compositions and methods involve providing to an organ before transplant or providing to a subject receiving a transplant an inhibitor of IGF-1R signaling and/or an inhibitor of GHR signaling.
Claims75
A method of extending lifespan of a transplant, the method comprising providing an inhibitor of insulin-like growth factor 1 receptor (IGF-1R) signaling and/or an inhibitor of growth hormone receptor (GHR) signaling to a subject before, during, and/or after a transplant in the subject.
A method of determining potential lifespan of a kidney transplant in a subject, comprising:
- a) determining the effective kidney dose (eKD) of the kidney transplant;
- b) determining levels of IGF-1 in a sample obtained from the subject, and
- c) determining potential lifespan of the kidney transplant in the subject based at least in part upon the eKD and the levels of IGF-1 in the sample obtained from the subject.
A method of extending lifespan of a transplant, the method comprising contacting a donor organ obtained from a deceased subject with an inhibitor of insulin-like growth factor 1 receptor (IGF-1R) signaling and/or an inhibitor of growth hormone receptor (GHR) signaling prior to transplant of the donor organ into a subject.
A method of extending kidney lifespan in a subject having kidney dysfunction, the method comprising providing an inhibitor of insulin-like growth factor 1 receptor (IGF-1R) signaling and/or an inhibitor of growth hormone receptor (GHR) signaling to a subject having kidney dysfunction.
Use of an inhibitor of insulin-like growth factor 1 receptor (IGF-1R) signaling in a method of extending lifespan of a transplant.
Use of an inhibitor of growth hormone receptor (GHR) signaling in a method of extending lifespan of a transplant.
Dependencies are inferred from the claim text.