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US 2026/0284111 A1Published application
Coreceptor chimeric antigen receptor
OwnerRudolf ÜBELHARTinventor
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Abstract
The present invention relates to a co-receptor chimeric antigen receptor (CoCAR) capable of binding LCK, combinations of a co-receptor chimeric antigen receptor and a CAR, nucleic acid constructs encoding such CoCAR, recombinant cells engineered to express such CoCAR and pharmaceutical compositions comprising the same. The present invention further provides the use thereof in the treatment of diseases preferably characterized by expression of a tumor-associated antigen.
Claims22
A coreceptor-CAR (CoCAR), comprising
- (i) a first extracellular antigen-recognition domain,
- (ii) a first hinge domain,
- (iii) a first transmembrane domain, and
- (iv) at least one cytosolic domain
- capable of binding LCK;
- wherein the CoCAR does not comprise a CD3zeta domain.
3 more elements
(canceled)
18-21. (canceled)
Dependencies are inferred from the claim text.