Methods of producing matured dendritic cells for immunotherapy
AssigneesThe Education University of Hong Kong, The Chinese University of Hong Kong, Hong Kong Baptist University
InventorsKin Lam Yung, Zhifeng Huang, Shiqing Zhang
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Abstract
Disclosed herein are methods for producing matured dendritic cells for immunotherapy. The disclosed methods include a) providing a biocompatible nanomatrix; b) seeding immature dendritic cells onto the biocompatible nanomatrix; and c) culturing the dendritic cells for a period sufficient to induce maturation via mechanical stimuli provided by the biocompatible nanomatrix. Also disclosed herein are the matured dendritic cells produced by the methods, as well as pharmaceutical compositions including the matured dendritic cells.
Claims20
A method of producing matured dendritic cells for immunotherapy, comprising:
- a) providing a biocompatible nanomatrix;
- b) seeding immature dendritic cells onto the biocompatible nanomatrix;
- and
- c) culturing the dendritic cells for a period sufficient to induce maturation via mechanical stimuli provided by the biocompatible nanomatrix.
Dependencies are inferred from the claim text.