Methods for enhancing vascular density
AssigneeMetro International Biotech, LLC
InventorsLindsay Edward Wu, David Andrew Sinclair, Abhirup Das
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Abstract
The present invention relates to methods of increasing vascular density and/or blood flow in tissue of a subject, and to increasing exercise capacity of a subject, the methods include administering to a subject an effective amount of an agent that elevates SIRT1 activity in endothelial cells of the subject, the invention further includes administering an NAD+ agonist or NAD+ precursor to a subject to increase vascular density and/or blood flow. The invention includes compositions comprising the said agent.
Claims14
1-60. (canceled)
A method of treating lung disease in a subject in need thereof, the method comprising administering to the subject an effective amount of a pharmaceutical composition comprising nicotinic acid mononucleotide (NaMN).
A method of treating lung disease in a subject in need thereof, the method comprising administering to the subject an effective amount of nicotinic acid mononucleotide (NaMN) in a sterile injectable aqueous solution by infusion.
Dependencies are inferred from the claim text.