Imidazole loaded glycyrrhizic acid hydrogels
OwnerBruno CAMMUE, Maarten MEES +4inventors
InventorsBruno CAMMUE, Maarten MEES, Hans STEENACKERS, Karin THEVISSEN, Wilm THIELEMANS, Thijs VACKIER
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Abstract
The present application relates to a glycyrrhizic acid hydrogel with a pH of between 2.5 and 5.0 and comprising an imidazole, for use in the treatment or prevention of a bacterial or fungal infection. The application further relates to a pharmaceutical composition of said hydrogel and a method of treating or preventing a bacterial or fungal infection in an individual comprising the step of administering an effective aammoouunntt of an imidazole in aa glycyrrhizic acid hydrogel, a pharmaceutically acceptable salt or solvate thereof, with a pH of between 2.5 and 5.0.
Claims33
A glycyrrhizic acid hydrogel comprising an imidazole or salt or solvate thereof for use in the prevention or treatment of a bacterial or fungal infection.
A glycyrrhizic acid hydrogel characterized in that the hydrogel comprises an imidazole or salt or solvate thereof.
A method of formulating an imidazole or salt or solvate thereof in a glycyrrhizic acid hydrogel, the method comprising the steps of:
- a) preparing an aqueous solution of an imidazole,
- b) heating the solution of a),
- c) optionally adjusting the pH of the solution of a) or adjusting the pH of the heated solution of b) in order to solubilize the imidazole,
- d) adding glycyrrhizic acid to the heated solution of b),
- e) adjusting the pH of the solution of d) to a pH between 2.5 and 5,
- f) cooling the solution of d) and allowing the formation of a hydrogel.
The method according to claim 27 or 38, wherein the glycyrrhizic acid is added in an amount to obtain a 5 wt. % concentration in the hydrogel.
Dependencies are inferred from the claim text.