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AssigneeBiolt S.R.L.S.
InventorsMaurizio Fraziano, Noemi Poerio, Tommaso Olimpieri
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The present invention relates to a liposome consisting of an outer leaflet comprising phosphatidylserine, and an inner leaflet comprising phosphatidylserine and phosphatidic acid, characterized in that the zeta potential of said liposome is between −25 mV and −100 mV, and the molar ratio between the total phosphatidylserine and the phosphatidic acid is between 5:1 and 35:1, more preferably between 16:1 and 18:1, even more preferably 17:1. The present invention also concerns the use of said liposome and/or of a composition which comprises it in the treatment of bacterial infections, preferably in the treatment of infections caused by mycobacteria, in particular nontuberculous mycobacteria.
A liposome consisting of an outer leaflet comprising phosphatidylserine, and an inner leaflet comprising phosphatidylserine and phosphatidic acid, wherein zeta potential of said liposome is between −25 mV and −100 mV and molar ratio between the total phosphatidylserine comprised on the outer and on the inner leaflet and the phosphatidic acid is between 5:1 and 35:1.
11-16. (canceled)
Dependencies are inferred from the claim text.