Contraceptive compositions and methods for improved efficacy and modulation of side effects
AssigneeAgile Therapeutics, Inc.
InventorsAgis Kydonieus, Michael E. Kafrissen, Katie Macfarlane
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Abstract
Compositions and methods for the delivery of progestin hormones that have binding affinity to the Sex Hormone Binding Globulin (SHBG) are disclosed. The compositions combine such progestins with non-progestin SHBG ligands to displace at least part of the progestin from SHBG in the blood plasma, thereby increasing its bioavailability. Also disclosed are methods to modulate progestin and estrogen levels in the blood through the use of SHBG binding and displacement, to optimize the effectiveness of formulations for contraception and minimize the side effects and adverse events.
Claims27
1-60. (canceled)
A patch for transdermal administration of a contraceptive composition, comprising levonorgestrel (LNG) and ethynyl estradiol (EE), wherein the patch transdermally administers a contraceptively effective amount of LNG and about 1 to 10 micrograms of EE per day when in contact with human skin.
Dependencies are inferred from the claim text.