Testosterone and difluoromethylornithine combination therapy for prostate cancer
AssigneeThe Johns Hopkins University
InventorsSamuel R. DENMEADE, Laura A. SENA, Robert A. CASERO
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Abstract
A method for treating prostate cancer by administering a first dose of a polyamine inhibitor for a first interval at a beginning of a first treatment cycle; a second dose of the polyamine inhibitor in combination with a dose of an androgen, or a derivative thereof, at a second interval during the first treatment cycle; and a dose of an antiandrogen at a third interval during the first treatment cycle is disclosed.
Claims54
A method for treating prostate cancer in a subject in need of treatment thereof, the method comprising administering to the subject:
- (a) a first dose of a polyamine inhibitor for a first interval at a beginning of a first treatment cycle;
- (b) a second dose of the polyamine inhibitor in combination with a dose of an androgen, or a derivative thereof, at a second interval during the first treatment cycle;
- and (c) a dose of an antiandrogen at a third interval during the first treatment cycle.
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Dependencies are inferred from the claim text.