Azepino Analogs and Methods of Making and Using the Same

A compound of Formula III:

• wherein
• is a single or double bond as needed to satisfy atom valences;
• W1 is NR1a when the to which W1 is attached is a single bond, or W1 is N when the to which W1 is attached is a double bond;
• W4 is C and one of the to which W4 is attached is a double bond;
• W5 is C and one of the groups to which W5 is attached is a double bond, wherein when the adjacent to R3 is a double bond then R31 and R3, are absent, and wherein when the adjacent to R30 and W5 is a double bond then R31 is absent and the between W5 and W4 is a single bond;
• Z4 is CR4;
• Z5 is CR5;
• Z6 is CR6;
• Z7 is CR7;
• R1a is selected from hydrogen, deuterium, optionally substituted C1-C8 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, —C(O)R8, —C(O)OR8, —P(O)(OR9)2, —C(O)N(R9)2, —SOR8, and —SO2R8;
• R3, R3′, R4, R5, R6, R7, R30, R44, R45, R46, R48, R50, R51, R51′, R60, and R61 are each independently selected from hydrogen, deuterium, —N(R9)2, —C(O)R8, —OC(O)OR8, —C(O)OR8, —OC(O)R3, —SR9, —P(O)(OR9)2, —C(O)N(R9)2, halo, hydroxyl, optionally substituted C1-C8 alkyl, optionally substituted —C1-C8 alkoxy, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl and —OSO2R3;
• R41, R42, and R43 are each independently selected from hydrogen, deuterium, —N(R9)2, —C(O)R3, —OC(O)OR3, —C(O)OR3, —OC(O)R3, —SR9, —P(O)(OR9)2, —C(O)N(R9)2, —OSO2R3, halo, hydroxyl, optionally substituted C1-C8 alkyl, optionally substituted —C1-C8 alkoxy, optionally substituted C2-C8 alkenyl and optionally substituted C2-C8 alkynyl, or R40 is taken together with R41 or R42, together with the carbons to which they are attached, to form an optionally substituted 3- to 9-membered heterocyclic ring optionally including 1 to 2 additional ring heteromoieties selected from O, S, S(O), SO2, and NR9, or R41 is taken together with R43, together with the carbons to which they are attached, to form an optionally substituted 3- to 9-membered heterocyclic ring optionally including 1 to 2 additional ring heteromoieties selected from O, S, S(O), SO2, and NR9;
• R40 is a substituted C1-C8 alkyl;
• R47 is —C(O)OR8;
• R8 is, independently for each occurrence, selected from hydrogen, deuterium, —N(R9)2, optionally substituted C1-C8 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted heteroaryl, and optionally substituted aryl;
• R9 is, independently for each occurrence, selected from hydrogen, deuterium, optionally substituted C1-C8 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted heteroaryl, and optionally substituted aryl,
• and salts, solvates, hydrates, enantiomers, polymorphs and prodrugs thereof.