Controlling homeostatic regulatory circuitry in hypothalamus
AssigneeThe Johns Hopkins University
InventorsSeth Blackshaw, Sooyeon Yoo, Leighton H. Duncan
Life of this patent
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Abstract
Provided herein are, inter alia, methods, compositions and kits for treating a hypothalamic-regulated behavior Also included herein are kits for treating a hypothalamic-regulated behavior.
Claims25
A method of preventing or treating a hypothalamic-regulated behavior in a subject, the method comprising,
- administering an effective amount of an agent to the subject, wherein the agent decreases the activity or expression of a nuclear factor I (NFI) gene, and
- wherein the hypothalamic-regulated behavior comprises obesity, type II diabetes, a sleep disorder, hypertension, anorexia nervosa, congenital hypothyroidism, neuropsychiatric disorders linked to dysregulation of cortisol, depression, or post-traumatic stress disorder.
17-21. (canceled)
A method for enhancing neurogenic competence in an glial cell in a subject, the method comprising administering an effective amount of an agent to the subject, wherein the agent wherein the agent decreases the activity or expression of a nuclear factor I (NFI) gene, and
- wherein neurogenic competence comprises outward radial migration, maturation, and integration into existing hypothalamic circuitry
23-24. (canceled)
(canceled)
A synthetic construct comprising a nucleic acid sequence of any one of SEQ ID NOs:
- 1-26 or combinations thereof;
- or
- An adeno-associated virus (AAV) comprising a nucleic acid molecule having a sequence identity of at least 75% to at least one of SEQ ID NOS:
- 1-26.
28-29. (canceled)
An isolated cell comprising a nucleic acid molecule having a sequence identity of at least 75% to at least one of SEQ ID NOS:
- 1-26;
- or
- An isolated cell comprising an adeno-associated virus (AAV) comprising a nucleic acid molecule having a sequence identity of at least 75% to at least one of SEQ ID NOS:
- 1-26.
31-34. (canceled)
Dependencies are inferred from the claim text.