US 2026/0284070 A1 · Ophthalmic Solution of Brinzolamide

Abstract

The present invention relates to an ophthalmic composition of Brinzolamide. More particularly, the present invention relates to an ophthalmic solution of Brinzolamide comprising Brinzolamide dispersed uniformly in a polymer in form of polymeric micelles. Further, the present invention relates to aqueous micelle solutions of Brinzolamide which provide a sustained Intra Ocular Pressure lowering effect. Further, the present invention relates to aqueous micelle solutions of Brinzolamide which are more bioavailable, efficacious and also provide a sustained Intra Ocular Pressure (IOP) lowering effect than, the currently marketed ophthalmic suspensions of Brinzolamide. The present invention also relates to stable ophthalmic aqueous micelle solutions of Brinzolamide.

Claims15

Dependent claims

An aqueous micelle solution comprising Brinzolamide dispersed uniformly in a polymer;

in the form of polymeric micelles;
and one or more pharmaceutically acceptable excipients;
wherein the polymer in the micelle is a polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft co-polymer;
and wherein the aqueous micelle solution does not contain a surfactant.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

19/479,042Filed 15 May 2024

Priority

IN 20234103421416 May 2023

Published

24 Sep 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification8 codes

A61K 31/542
Having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame: ortho- or peri-condensed with…
A61K 9/0048
Galenical forms characterised by the site of application: eye, e.g. artificial tears
A61K 9/10
Medicinal preparations characterised by special physical form: dispersions; Emulsions
A61K 9/1075
Emulsions ; Emulsion preconcentrates; Micelles: microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of…

Ophthalmic Solution of Brinzolamide

Life of this patent

Ophthalmic Solution of Brinzolamide

Life of this patent

Abstract

Claims15