Mek inhibitor for treatment of stroke
AssigneeEdvince AB
InventorLars EDVINSSON
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Abstract
The present invention relates to a MEK inhibitor and compositions thereof, for use in the treatment of stroke, in particular treatment of subarachnoid haemorrhage (SAH)
Claims21
A method of treating or reducing the risk of developing a stroke in a subject, wherein the method comprises the steps of administering a compound of formula (I):
- or a pharmaceutically acceptable salt thereof,
- wherein;
- R1 is a C1-C6 alkyl,
- R2 is a C1-C6 alkyl, such as cyclopropyl, and
- Ar is selected from the group consisting of aryl and heteroaryl;
- to a subject in need thereof, thereby treating or reducing the risk of developing a stroke.
The method according to claim 18, wherein the intracerebral haemorrhage is intraparenchymal, intraventricular, or a combination thereof.
The method according to claim 22, wherein the DCI presents with inflammation, oedema, delayed cerebral vasospasm (CVS), blood-brain barrier disruption and/or increase in contractile receptor expression, such as those for endothelin, angiotensin, serotonin and thromboxane or prostaglandins.
A method for:
- a. reducing endothelin-1 induced contractility;
- b. increasing endothelin B receptor function;
- and/or
- c. improving neurological score, which may be evaluated by a subject's ability to traverse a rotating pole, after induced subarachnoid haemorrhage;
- wherein the method comprises the steps of administering a compound of formula (I):
- or a pharmaceutically acceptable salt thereof,
- wherein;
- R1 is a C1-C6 alkyl,
- R2 is a C1-C6 alkyl, such as cyclopropyl, and
- Ar is selected from the group consisting of aryl and heteroaryl;
- to a subject in need thereof.
A composition comprising, separately or together, a compound of formula (II):
- or a pharmaceutically acceptable salt thereof, and a further medicament that is a calcium channel blocker, such as Nimodipine, or an endothelin receptor (ET) receptor blocker, such as clazosentan.
Dependencies are inferred from the claim text.