Compounds for upregulating utrophin levels in muscle cells and method of application thereof
AssigneePeptris Technologies Private Limited
InventorsAnand Budni, Venkatasubramanian Narayanan, Shridhar Narayanan
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Abstract
Disclosed herein are compounds for the treatment or management or both of muscular dystrophy. The compounds, according to the embodiments herein, are capable of inhibiting DPP-IV activity, thereby upregulating utrophin levels in muscles, resulting in an overall improvement in muscle function. Embodiments herein also achieve a composition for upregulating utrophin levels in muscle cells.
Claims54
A compound or its pharmaceutically acceptable salt for the preparation of a medicament for the treatment or management or both of muscular dystrophy, wherein the compound is a DPP-IV inhibitor selected from a group consisting of Sitagliptin, Melogliptin, Linagliptin, Vildagliptin, Teneligliptin, Saxagliptin, Alogliptin, Anagliptin, Gemigliptin, Trelagliptin, Omarigliptin, Evogliptin, Gosogliptin, Retagliptin, Cofrogliptin, Fotagliptin, Prusogliptin and combinations thereof.
Dependencies are inferred from the claim text.