Preventive or therapeutic agent for neurodegenerative disease
AssigneesMedilabo Rfp, Inc., University Public Corporation Osaka
InventorsToru KUMAGAI, Takami TOMIYAMA, Tomohiro UMEDA
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Abstract
The purpose of the present invention is to provide a medicinal agent that exhibits the effect of inhibiting aggregation of a causative protein of an HRE-related neurodegenerative disease such as ALS. According to the present invention, rifampicin or a rifampicin compound selected from the group consisting of rifampicin, a derivative thereof, and a salt of rifampicin or the derivative and/or resveratrol or a resveratrol compound selected from the group consisting of resveratrol and a derivative thereof is an active ingredient of a preventive or therapeutic agent for a neurodegenerative disease caused by TDP-43 accumulation, or an active ingredient of a preventive or therapeutic agent for ALS.
Claims19
A preventive or therapeutic agent for a neurodegenerative disease caused by accumulation of TDP-43, comprising, as an active ingredient, a resveratrol compound selected from the group consisting of resveratrol and a derivative of resveratrol.
A preventive or therapeutic agent for amyotrophic lateral sclerosis (ALS), comprising, as an active ingredient, a resveratrol compound selected from the group consisting of resveratrol and a derivative of resveratrol.
A preventive or therapeutic agent for a neurodegenerative disease caused by C9orf72 gene abnormality and/or TDP-43 gene abnormality, comprising, as an active ingredient, a resveratrol compound selected from the group consisting of resveratrol and a derivative of resveratrol.
A preventive or therapeutic agent for a neurodegenerative disease caused by accumulation of TDP-43, comprising a combination of a rifampicin compound selected from the group consisting of rifampicin, a derivative of rifampicin, and a salt of rifampicin or the derivative, and a resveratrol compound selected from the group consisting of resveratrol and a derivative of resveratrol.
A preventive or therapeutic agent for a neurodegenerative disease caused by accumulation of TDP-43, comprising, as an active ingredient, a rifampicin compound selected from the group consisting of rifampicin, a derivative of rifampicin, and a salt of rifampicin or the derivative.
A preventive or therapeutic agent for amyotrophic lateral sclerosis (ALS), comprising, as an active ingredient, a rifampicin compound selected from the group consisting of rifampicin, a derivative of rifampicin, and a salt of rifampicin or the derivative.
A preventive or therapeutic agent for a neurodegenerative disease caused by C9orf72 gene abnormality and/or TDP-43 gene abnormality, comprising, as an active ingredient, a rifampicin compound selected from the group consisting of rifampicin, a derivative of rifampicin, and a salt of rifampicin or the derivative.
Dependencies are inferred from the claim text.