Dual inhibitors of dyrk1a and 5-ht2 for treating a brain disorder

A method of treating a brain disorder, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula I or Formula II:

• or a pharmaceutically acceptable salt thereof, in an amount sufficient to increase neuronal plasticity of the neuronal cell, wherein:
• R1a, R1b, and R1c are each independently hydrogen, C1-6 alkyl, C3-8 cycloalkyl, or C4-14 alkyl-cycloalkyl;
• alternatively, two of R1a, R1b, and R1c are combined with the atoms to which they are attached to form a C3-12 heterocycloalkyl;
• Ring A is a 5 to 6 membered heteroaryl ring having 1 to 3 heteroatoms each independently N, O, or S, substituted with 0 to 3 R2 groups;
• R2, R4, R5, R6 and R7 are each independently hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, halogen, C1-6 haloalkyl, C1-6 alkylamine, C1-6 alkoxy, C1-6 haloalkoxy, —OR8a, —NO2, —CN, —C(O)R8b, —C(O)OR8b, —OC(O)R8b, —OC(O)OR8b, —N(R8bR8c), —N(R8b)C(O)R8c, —C(O)N(R8bR8c), —N(R8b)C(O)OR8c, —OC(O)N(R8bR8c), —N(R8b)C(O)N(R8cR8d), —C(O)C(O)N(R8bR8c), —S(O2)R8b, —S(O)2N(R8bR8c), C3-8 cycloalkyl, C3-14 alkyl-cycloalkyl, C4-10 heterocycloalkyl, C4-16 alkyl-heterocycloalkyl, C6-12 aryl, C7-18 alkyl-aryl, C5-10 heteroaryl, or C4-16 alkyl-heteroaryl;
• alternatively, R4 and R5, R5 and R6, or R6 and R7 are combined with the atoms to which they are each attached to form a C3-6 cycloalkyl, C3-6 heterocycloalkyl, C6-12 aryl, or C5-10 heteroaryl;
• and
• R3 is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, halogen, C1-6 haloalkyl, C1-6 alkylamine, C1-6 alkoxy, C1-6 haloalkoxy, —OR8a, —NO2, —CN, —C(O)RBb, —C(O)OR8b, —OC(O)R8b, —OC(O)OR8b, —N(R8bR8c), —N(R8b)C(O)R8c, —C(O)N(R8bR8c), —N(R8b)C(O)OR8c, —OC(O)N(R8bR8c), —N(R8b)C(O)N(R8cR8d), —C(O)C(O)N(R8bR8c), —S(O2)R8b, —S(O)2N(R8bR8c), C3-8 cycloalkyl, C3-14 alkyl-cycloalkyl, C4-10 heterocycloalkyl, C4-16 alkyl-heterocycloalkyl, C6-12 aryl, C7-18 alkyl-aryl, C5-10 heteroaryl, or C4-16 alkyl-heteroaryl;
• R8a is C3-8 cycloalkyl, C3-14 alkyl-cycloalkyl, C4-10 heterocycloalkyl, C4-16 alkyl-heterocycloalkyl, C6-12 aryl, C7-18 alkyl-aryl, C5-10 heteroaryl, or C4-16 alkyl-heteroaryl;
• R8b, R8c and R8d are each independently H or C1-6 alkyl;
• X is O or S;
• and
• L is C1-6 alkylene.