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US 2026/0284014 A1Published application
3,5-diaminotriazole derivatives and uses thereof for treating ocular diseases
AssigneesCentre National De La Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Université CôTe D'Azur
InventorsRACHID BENHIDA, MAEVA DUFIES, MARIE FABRE, LETICIA GONCALVES-PIRES, JULIE LE DU, GILLES PAGES, OLIVIA RASTOIN, CYRIL RONCO
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Abstract
The present invention relates to 3,5-diaminotriazole derivatives of formula (I) and pharmaceutical or veterinary compositions comprising such derivatives. It further relates to the compounds of formula (I) for use for treating an ocular disease, preferably diabetic retinopathy, macular degeneration, neovascular glaucoma, macular oedema or Stargardt's disease.
Claims19
1-16. (canceled)
A compound of formula (I):
- wherein:
- X is —(CH2)—, —(CH2)—CO—, or —(CH2)—(CH2)—;
- R1 is an aryl or a heteroaryl group, said aryl or heteroaryl groups are optionally substituted by at least one radical selected from the group consisting of a (C1-C6)alkyl optionally substituted by at least one halogen, a (C1-C6)alkyloxy optionally substituted by at least one halogen, a halogen, a —CO2R3 with R3 being a hydrogen or a (C1-C6)alkyl, and a —C(O)R4 with R4 being a hydrogen, a (C1-C6)alkyl, or a —NR5R6 with R5 and R6 are independently a hydrogen or a (C1-C6)alkyl, a nitrile, and a nitro;
- n is 0, 1, 2, 3, 4, or 5;
- each R2 is independently a radical selected from the group consisting of a (C1-C6)alkyl optionally substituted by at least one halogen, a (C1-C6)alkyloxy optionally substituted by at least one halogen, a halogen, a —CO2R3 with R3 being a hydrogen or a (C1-C6)alkyl, and a —C(O)R4 with R4 being a hydrogen, a (C1-C6)alkyl, or a —NR5R6 with R5 and R6 are independently a hydrogen or a (C1-C6)alkyl, a nitrile, and a nitro;
- with the proviso that said compound is not a compound selected from the group consisting of:
- 1-benzyl-N3-phenyl-1H-1,2,4-triazole-3,5-diamine;
- and
- 1-phenethyl-N3-phenyl-1H-1,2,4-triazole-3,5-diamine
- or a pharmaceutically acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.