Solid dispersion of p2x4 inhibitor, and preparation method therefor and use thereof

Abstract

A solid dispersion of a P2X4 inhibitor, comprising an active ingredient and a carrier. The obtained solid dispersion can improve the solubility and dissolution effect of the active ingredient, has a good stability, and has no obvious increase in impurities under 25° C./60% RH (open) and 40° C./75% RH (open) conditions. The method for preparing the solid dispersion is simple. The solid dispersion can be prepared using a spray drying method, a solvent method, or a hot-melt extrusion method, and the solvent residue content in the obtained product is qualified. Furthermore, the obtained solid dispersion effectively improves the pharmacokinetic effect of the active ingredient. A pharmaceutical composition containing the solid dispersion. The pharmaceutical composition has a good disintegration effect, and the disintegration time is within pharmacopoeial limits. Therefore, the pharmaceutical composition provides convenience for the development of subsequent dosage forms of the active ingredient.

Dependencies are inferred from the claim text.