Ferroptosis inhibitors

A quinone according to formula (III)

• wherein
• R16 and R17 are independently selected from the group consisting of H and —OH;
• R18 is selected from the group consisting of H, —(C1-C30)alkyl, trifluoromethyl;
• R19 is
• D is N;
• E is a bond, (C1-C8)alkylene, or (C2-C8)alkenylene;
• R20 is selected from the group consisting of H, —COOH, —CONH2, —COO(C1-C6)alkyl;
• R21, R22, R23, R24, R25 are independently selected from the group consisting of H, (C1-C4) alkyl, —O(C1-C4)alkyl, —OH, halogen, —CF3, —CO(C1-C4)alkyl, COOH, —COO(C1-C6)alkyl, —CONH2, —NH2, —NHCO(C1-C4)alkyl, —NH(C1-C4)alkyl, and —N((C1-C4)alkyl)2;
• preferably H, —(C1-C4) alkyl, —O(C1-C4)alkyl, —OH, Cl, F, —CF3, —CO(C1-C4)alkyl, and COOH;
• more preferably H, —(C1-C4) alkyl, —O(C1-C4)alkyl, —OH, Cl, —CO(C1-C4)alkyl, and COOH;
• wherein in (C1-C30)alkyl, one or more hydrogen atoms are optionally independently substituted by a substituent selected from the group consisting of —OH, —O(C1-C10)alkyl, (C1-C10)alkyl, —C(O)(C1-C10)alkyl, —COO(C1-C10)alkyl, —CONH2, —COOH, —(C6-C12)aryl;
• wherein the conditions i) and ii) are not present in the same molecule:
• i) E is a bond, R20 is H,
• ii) R18 is H;
• or a pharmaceutically acceptable salt, solvate, enantiomer, diastereomer, racemate or hydrate thereof.