Nanoparticle compositions comprising one or more variants or poly (d,l-lactic-co-glycolic acid)

A nanoparticle composition comprising a cationic or cationically ionisable lipid or lipid-like material, a helper lipid, a lipopolymer, and one or more variants of poly(D,L-lactic-co-glycolic acid) (PLGA),

• wherein the cationic or cationically ionisable lipid or lipid-like material is selected from the group consisting of 1,1′-((2-(4-(2-((2-(bis(2-hydroxydodecyl)amino)ethyl)(2-hydroxydodecyl)amino)ethyl) piperazin-1-yl)ethyl)azanediyl)bis(dodecan-2-ol) (C12-200), N1,N16-didodecyl-4,7,13-tris[3-(dodecylamino)-3-oxopropyl]-4,7,10,13-tetraazahexadecanediamide (98N12-5), tetrakis(8-methylnonyl) 3,3′,3″,3′″-(((methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrapropionate (306Oi10), 3,3′,3″,3′″-(ethane-1,2-diylbis(azanetriyl))tetrakis(N-(2-((2-hydroxytetradecyl)amino)ethyl)propanamide) (GO-C14), N1,N3,N5-tris(3-(didodecylamino)propyl)benzene-1,3,5-tricarboxamide (TT3), dilinoleylmethyl-4-dimethylaminobutyrate (DLin-MC3-DMA), 2,2-dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane (DLin-KC2-DMA), hexa(octan-3-yl) 9,9′,9″,9′″,9″″,9′″″-((((benzene-1,3,5-tricarbonyl)yris(azanediyl)) tris (propane-3,1-diyl)) tris(azanetriyl))hexanonanoate (FTT5), 1,2-dioleoyl-3-trimethylamonniumpropane (DOTAP), dimethyldioctadecylammonium bromide (DDAB), 1,2-dioleoyl-3-dimethylammonium-chloride (DODAC), 1,2-di-O-octadecenyl-3-trimethylammonium propane (DOTMA) and 8-[(2-hydroxyethyl)[6-oxo-6-(undecyloxy)hexyl]amino]-octanoic acid, 1-octylnonyl ester (SM-102), 2-hexyl-decanoic acid, 1,1′-[[(4-hydroxybutyl)imino]di-6,1-hexanediyl]ester (ALC-0315), 2-[3-[3-[3-[bis[3-[2-(2-methyl-3-octylsulfanylpropanoyl)oxyethoxy]-3-oxopropyl]amino]propyl-methylamino]propyl-[3-[2-(2-methyl-3-octylsulfanylpropanoyl)oxyethoxy]-3-oxopropyl]amino]propanoyloxy]ethyl 2-methyl-3-octylsulfanylpropanoate(4A3-SC8) (4A3-SC8), or any mixture thereof,
• wherein the helper lipid is selected from the group consisting of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), and 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine (DMPC), or any mixture thereof, and
• wherein the lipopolymer is a polyethylene glycol (PEG)- or polysarcosine-lipid conjugate, or a PEG- or polysarcosine-lipid like conjugate, or any mixture thereof.