Formulations of phospholipid carrier complexes
OwnerJoseph Halstead, Oliver J. Ratcliffeinventors
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Abstract
The present disclosure provides formulations for biologically active molecules including steroid hormones, diarylheptanoids, vitamins and flavonoids. These formulations are distinguished from the prior art through the inclusion of magnesium stearate or a salt with comparable properties along with a phospholipid carrier complex. These formulations provide for more convenient modes of delivery, such as via orally consumed capsules containing a solid powder. The present disclosure also provides for the use of combinations of biologically active molecules flavonoids and/or steroid hormone, including the combined delivery of the hormone testosterone and curcuminoid compounds to human and/or animal subjects.
Claims30
A chemical formulation comprising (i) a molecule of interest selected from the group consisting of a diarylheptanoid, flavonoid, vitamin or steroid hormone;
- (ii) a liposomal carrier complex;
- and (iii) magnesium stearate or a salt with comparable properties to magnesium stearate.
A method of treating a subject in need thereof comprising administering to the subject a drug comprising a chemical formulation comprising a molecule of interest selected from the group consisting of flavonoid, a diarylheptanoid, and a steroid hormone, combined with a liposomal carrier complex, and magnesium stearate or a salt with comparable properties to magnesium stearate.
A method for producing a chemical formulation comprising the steps of:
- (a) blending a dry mixture comprising a molecule of interest that is soluble in an organic solvent, a liposomal carrier complex, and magnesium stearate or a salt with comparable properties to magnesium stearate;
- (b) adding the organic solvent to the dry mixture and mixing to produce a uniform homogeneous slurry;
- (c) removing the organic solvent by evaporation to leave a solid uniform mass;
- and
- (d) pulverizing the solid uniform mass into a powder.
A method for producing a chemical formulation containing a water-soluble molecule of interest, comprising the steps of:
- (a) dissolving the water-soluble molecule of interest in water to form an aqueous solution;
- (b) providing a mixture comprising a liposomal carrier complex and magnesium stearate or a salt with comparable properties to magnesium stearate;
- (c) adding an organic solvent and the aqueous solution of step (a) to the mixture of step (b) to produce a uniform homogeneous slurry;
- (d) removing the water and organic solvent by evaporation to leave a solid uniform mass;
- and
- (e) pulverizing the solid uniform mass into a powder.
Dependencies are inferred from the claim text.