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US 2026/0283922 A1Published application
Particles of Hydrophobic-Chain-Modified Monosaccharides and Cyclodextrin
OwnerKawthar BOUCHEMAL, Jean-Maurice MALLETinventors
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Abstract
The present invention relates to particles comprising at least one monosaccharide modified with a hydrophobic chain, at least one cyclodextrin, and optionally a molecule of therapeutic or cosmetic interest, to the preparation method thereof, to a pharmaceutical or cosmetic composition comprising same, and to the use thereof for the sustained release of molecules of cosmetic or therapeutic interest. The invention also relates to said modified monosaccharide.
Claims21
Particles comprising:
- at least one compound having the following formula:
- in which
- n represents 0 or 1;
- M represents a residue of a monosaccharide of which an OH is replaced by the group —X-(A-Y)n-Z and of which one or more —OH groups are optionally replaced by a group —OSO3H and/or of which a group —CH2—OH is optionally replaced by a group —COOH;
- X represents —O—, —S—, —NR1—, —OC(O)—, —SC(O)—, —N(R1)C(O)—, —OC(S)—, —SC(S)—, or —N(R1)C(S)—, the first atom of the groups being linked to M;
- A represents a linker, the linker being a (C1-C20)alkyl chain, optionally interrupted one or more times by one or more moieties selected from the group consisting of —O—, —S—, —NR2—, —C(O)—, and —C(S)—, and/or optionally substituted with one or more groups selected from the group consisting of a halogen atom, —NO2, —CN, —OR3, —SR4, and —NR5R6;
- Y represents —O—, —S—, —NR7—, —C(O)—, —C(S)—, —OC(O)—, —C(O)O—, —SC(O)—, —C(O)S—, —N(R7)C(O)—, —C(O)N(R7)—, —OC(S)—, —C(S)O—, —SC(S)—, —C(S)S—, —N(R7)C(S)—, or —C(S)N(R7)—;
- R1 to R7 represent, independently of each other, a hydrogen atom or a (C1-C6)alkyl group;
- and
- Z represents a saturated or unsaturated hydrocarbon chain comprising from 4 to 40 carbon atoms;
- at least one cyclodextrin.
8 more elements
13-14. (canceled)
Dependencies are inferred from the claim text.