Systems and methods for calibrating computed tomography breathing amplitudes for image reconstruction

A method for reducing motion artifacts in cone-beam computed tomography (CBCT) image reconstruction of a subject, comprising:

• accessing first CBCT data of the subject acquired with a cone-beam CT imaging system in a first scan and breathing amplitude signal data of the subject acquired with the first CBCT data;
• accessing second CBCT data of the subject acquired with the cone-beam CT imaging system in a second scan and breathing amplitude signal data of the subject acquired with the second CBCT data;
• generating a breathing motion model and motion model data based on the first CBCT data and corresponding breathing amplitude signal data;
• cross-calibrating the breathing amplitude signal data, wherein cross-calibrating the breathing amplitudes comprises simulating CBCT projection images using the first CBCT data and determining at least one breathing amplitude corresponding to the first CBCT data that provides a corresponding simulated CBCT projection to an actual projection image, providing a correspondence between the breathing amplitudes corresponding to the first CBCT data and the breathing amplitudes corresponding to the second CBCT data,
• reconstructing the second CBCT data using the breathing motion model based on the first CBCT data and the breathing amplitude corresponding to the first CBCT data.

A system for reducing motion artifacts in cone-beam computed tomography (CBCT) image reconstruction of a subject, the system comprising:

• a processor device;
• and
• a non-transitory computer-readable memory storing instructions executable by the processor device, wherein the instructions, when executed by the processor device, cause the system to:
• access CBCT data of the subject acquired with a cone-beam CT imaging system and breathing amplitude signal data of the subject acquired with the CBCT data;
• access model-based CT (MBCT) data of the subject acquired with a CT imaging system and breathing amplitude signal data of the subject acquired with the MBCT data;
• generate a breathing motion model and motion model data based on the MBCT data and corresponding breathing amplitude signal data;
• cross-calibrate the breathing amplitude signal data, wherein cross-calibrating the breathing amplitudes comprises simulating CBCT projection images using the MBCT data and determining at least one breathing amplitude corresponding to the MBCT data that provides a corresponding simulated CBCT projection to an actual projection image, providing a correspondence between the breathing amplitudes corresponding to the MBCT data and the breathing amplitudes corresponding to the CBCT data;
• and
• reconstruct the CBCT data using the breathing motion model based on the MBCT data and the breathing amplitude corresponding to the MBCT data.