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US 2026/0283471 A1Published application
Hyperspectral medical imaging platform and methods
AssigneeSpectraServe LLC
InventorsMichael B. Wong, Michael A. de Jong
Life of this patent
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Abstract
Systems and methods for generating hyperspectral medical images capable of producing and processing hyperspectral images of in vivo or ex vivo tissue samples. In processing hyperspectral images, the systems and methods are capable of producing pseudocolor or color-coded images, indicating various tissue types present in the image. The systems and methods may be especially useful for surgical margin assessment, including intraoperative surgical margin assessment, for example, for determining surgical margins during tumor resection.
Claims14
A hyperspectral medical imaging system for imaging a tissue, the hyperspectral medical imaging system comprising:
- a. a light source configured to emit incident light, the incident light reflecting off the tissue as reflected light, passing through the tissue as transmitted light, or a combination thereof;
- b. a transmissive optical component configured to transmit the reflected light, the transmitted light, or the combination thereof;
- c. a hyperspectral sensor configured to detect a property of the reflected light, the transmitted light, or the combination thereof transmitted through the transmissive optical component, the hyperspectral sensor further configured to capture a raw hyperspectral image and transmit the raw hyperspectral image to a computing device;
- d. the computing device operatively connected to the hyperspectral sensor, the computing device comprising a processor capable of executing computer-readable instructions and a memory component comprising the computer-readable instructions, wherein the computing device is configured to process the raw hyperspectral image to produce a processed hyperspectral image, and transfer the processed hyperspectral image to the memory component;
- and
- e. a display operatively connected to the computing device, wherein the computing device is further configured to read the processed hyperspectral image from the memory component and display the processed hyperspectral image on the display;
- wherein the raw hyperspectral image is processed in real-time such that the processed hyperspectral image displayed on the display is displayed and updated in five seconds or less.
4 more elements
A method of producing a hyperspectral image comprising:
- a. illuminating an in vivo or ex vivo tissue specimen with a light source;
- b. obtaining a scout image of the tissue specimen using a hyperspectral sensor to increase a hyperspectral image quality;
- c. obtaining the hyperspectral image by capturing a reflectance spectrum of a face of the tissue specimen, a transmission spectrum of light through the tissue, or a combination thereof using the hyperspectral sensor;
- d. saving the hyperspectral image as a datafile to a computing device, the computing device comprising a processor capable of executing computer-readable instructions and a memory component comprising computer-readable instructions for processing the hyperspectral image obtained by the hyperspectral sensor;
- e. obtaining at least one endmember from at least one of the hyperspectral image or an endmember library, wherein the at least one endmember is a reference candidate spectrum, wherein the at least one endmember represents a material in wavelength bands used to collect the hyperspectral image;
- f. using the computing device to process the datafile to unmix the hyperspectral image against the at least one endmember;
- g. using the computing device to generate a color-coded image from an unmixed hyperspectral image;
- and
- h. displaying the color-coded image on a display operatively connected to the computing device;
- wherein the color-coded image contains one or more pixels whose color is determined by the at least one endmember.
7 more elements
A hyperspectral medical imaging system for imaging a tissue, the hyperspectral medical imaging system comprising:
- a. a light source emitting broadband light from about 400 nm to about 2500 nm, the light source configured to emit incident broadband light, the incident broadband light reflecting off the tissue as reflected light, passing through the tissue as transmitted light, or a combination thereof;
- b. a polarizer configured to filter and transmit the reflected light, the transmitted light, or the combination thereof;
- c. one or more optical components configured to focus and transmit the reflected light, the transmitted light, or the combination thereof to a spectrograph;
- d. the spectrograph configured to separate the incident light into separate bands and focus them on a hyperspectral sensor;
- e. the hyperspectral sensor configured to detect a property of the reflected light, the transmitted light, or the combination thereof, the hyperspectral sensor further configured to capture a raw hyperspectral image and transmit the raw hyperspectral image to a computing device;
- f. the computing device operatively connected to the hyperspectral sensor, wherein the computing device comprises a processor capable of executing computer-readable instructions and a memory component comprising computer-readable instructions, wherein the computing device is configured to process the raw hyperspectral image to produce a processed hyperspectral image, and transfer the processed hyperspectral image to the memory component;
- and
- g. a display operatively connected to the computing device the display and the hyperspectral sensor, wherein the computing device is further configured to read the processed hyperspectral image from the memory component and display the processed hyperspectral image on the display.
5 more elements
Dependencies are inferred from the claim text.