Development and application of synthetic inhibitors of photosynthesis
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsGilles Basset, Lauren Stutts, Scott Latimer
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Abstract
The subject matter described herein is directed to herbicidal compounds, herbicidal compositions, methods of inhibiting photosynthesis using an herbicidal compound or composition described herein, and methods of inhibiting growth using an herbicidal compound or composition described herein. Also described is the biosynthesis of methylated plastoquinone-9 and its acute toxicity for plants and cyanobacteria. Additionally, the herbicidal activity of structural analogues of methyl-plastoquinone-9 (Me-PQ-9), which also display acute phytotoxicity at similar or lower concentrations than commercial herbicides.
Claims55
A method of inhibiting photosynthesis in a prokaryotic or eukaryotic organism capable of photosynthesis, wherein the method comprises:
- contacting the prokaryotic or eukaryotic organism capable of photosynthesis with an effective amount of a herbicide compound comprising a compound of Formula I:
- wherein,
- R1 is halogen, C1-C6 alkyl, C1-C6 alkoxy, or substituted C1-C6 alkyl;
- R2 is selected from the group consisting of:
- H, C1-C6 alkyl, substituted C1-C6 alkyl, C2-C50 alkenyl, and substituted C2-C50 alkenyl;
- and
- R3 and R4 are each independently selected from the group consisting of:
- H, halogen, C1-C6 alkyl, substituted C1-C6 alkyl, C1-C6 alkoxy, substituted C1-C6 alkoxy, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl;
- or
- R3 and R4 together with the carbon atoms to which each is attached can come together to form a ring selected from the group consisting of C3-C10 cycloalkyl, substituted C3-C10 cycloalkyl, C5-C10 aryl, substituted C5-C10 aryl, C3-C10 heterocycloalkyl, substituted C3-C10 heterocycloalkyl, C5-C10 heteroaryl, and substituted C5-C10 heteroaryl.
A method of inhibiting growth of a plant comprising:
- contacting the plants with an effective amount of an herbicide compound comprising a compound of Formula I:
- wherein,
- R1 is halogen, C1-C6 alkyl, C1-C6 alkoxy, or substituted C1-C6 alkyl;
- R2 is selected from the group consisting of:
- H, C1-C6 alkyl, substituted C1-C6 alkyl, C2-C50 alkenyl, and substituted C2-C50 alkenyl;
- and
- R3 and R4 are each independently selected from the group consisting of H, halogen, C1-C6 alkyl, substituted C1-C6 alkyl, C1-C6 alkoxy, substituted C1-C6 alkoxy, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl;
- or
- R3 and R4 together with the carbon atoms to which each is attached can come together to form a ring selected from the group consisting of C3-C10 cycloalkyl, substituted C3-C10 cycloalkyl, C5-C10 aryl, substituted C5-C10 aryl, C3-C10 heterocycloalkyl, substituted C3-C10 heterocycloalkyl, C5-C10 heteroaryl, and substituted C5-C10 heteroaryl.
An herbicidal compound comprising the following structure:
Dependencies are inferred from the claim text.