Purification process for the preparation of non-carrier added copper-64
AssigneeCurium US LLC
InventorsDavid Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst, Shaun Loveless
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AssigneeCurium US LLC
InventorsDavid Pipes, Lauren Radford, William Uhland, Brian Regna, Craig Brunkhorst, Shaun Loveless
Estimating the term…
Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
A method comprising isolating a copper-64 (64Cu) composition having a specific activity from 350 mCi 64Cu/μg Cu to 3,000 mCi 64Cu/μg Cu, wherein the 64Cu composition is isolated from a single target.
A method comprising isolating a copper-64 (64Cu) composition having a specific activity from 500 mCi 64Cu/μg Cu to 3,000 mCi 64Cu/μg Cu and a radionuclidic purity greater than 99%, wherein the 64Cu composition is isolated from a single target and is suitable for one or more patient doses.
Dependencies are inferred from the claim text.