Noninvasive Determination of Resting State Diastole Hemodynamic Information

A method comprising:

• performing a three-dimensional computational fluid dynamics (CFD) simulation of a three-dimensional electronic model representative of an anatomical region of a patient based on a boundary condition model specific to a diastole period of a cardiac cycle at a resting state of the patient, wherein the boundary condition model comprises at least one inflow rate and at least one outflow rate of the three-dimensional electronic model;
• calculating, according to the CFD simulation, a pressure drop between a first location of the anatomical region and a second location of the anatomical region;
• and
• determining, based on the calculated pressure drop and based on a reference pressure, a hemodynamic index value indicative of a lesion within the anatomical region.

A system comprising:

• a non-transitory, computer-readable memory storing instructions;
• and
• a processor configured to execute the instructions to:
• obtain a boundary condition model that is specific to a diastole period of a cardiac cycle at a resting state of a patient, wherein the boundary condition model comprises at least one inflow rate and at least one outflow rate at a boundary of a three-dimensional electronic model of an anatomical region of the patient;
• perform a three-dimensional computational fluid dynamics (CFD) simulation of the three-dimensional electronic model based on the boundary condition model;
• calculate, according to the CFD simulation, a pressure drop between a first location of the anatomical region and a second location of the anatomical region;
• and
• determine, based on the calculated pressure drop and based on a reference pressure, a hemodynamic index value indicative of a lesion within the anatomic region.

A method comprising:

• obtaining a boundary condition model that is specific to a diastole period of a cardiac cycle at a resting state of a patient, wherein the boundary condition model comprises at least one inflow rate and at least one outflow rate at a boundary of a three-dimensional electronic model of an anatomical region of the patient;
• calculating, based on the three-dimensional electronic model and the boundary condition model, at a first time point in a cardiac cycle of the patient, a first pressure drop across a portion of the anatomical region;
• calculating, based on the three-dimensional electronic model and the boundary condition model, at a second time point in a cardiac cycle of the patient that is different than the first time point, a second pressure drop across the anatomical region;
• calculating, for a range of time points of the cardiac cycle of the patient, respective pressure drops across the anatomical region according to the first and second pressure drops;
• and
• determining, based on the calculated pressure drops for the range of time points and based on a reference pressure, a hemodynamic index value.