Miniature modular detachable image-observation base device

A miniature modular detachable image-observation base device, configured for use in non-linear optical high-resolution neuroimaging monitoring, comprising:

• a composite lens unit comprising a miniaturized gradient-index lens and a micro coupling lens;
• and
• a wearable optical base having a lower edge, the lower edge having a curved surface that matches a natural curvature of a mouse's skull, with magnetic holes disposed on an upper side of the wearable optical base and configured to engagingly receive magnets to allow the magnets to be coupled to the wearable optical base and fixed firmly thereto by magnetic attraction, the magnets corresponding in number to the magnetic holes, with the composite lens unit detachably mounted inside the wearable optical base to allow the composite lens unit to be firmly fixed to the mouse's head through the wearable optical base, the composite lens unit being replaceable with others to accommodate observation applications at different depths to not only overcome limitations of shallow brain regions but also provide the miniaturized gradient-index lens being slender and thus able to pierce the mouse's brain to reach deep brain regions thereof, so as to steadily perform functional imaging monitoring of neuronal activity in the deep brain regions during numerous sessions over prolonged periods.