Systems and methods for determining compression properties of a powder and useful, for example, with tablet formulation development
AssigneeRegents of the University of Minnesota
InventorsChangquan Calvin Sun, Gerrit Vreeman
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Abstract
Systems and methods for analyzing powder compaction data to extract or derive parameters of the powder. With methods of the present disclosure, in-die compaction simulator data is collected and analyzed, and requires only a relatively small quantity of material. The systems and methods can utilize an additive mathematical model of powder compressibility during uniaxial compaction by combining bulk elasticity, linear and non-linear, and low-to-medium pressure densification processes for assessing a powder material under consideration.
Claims18
A method of assessing a powder material, the method comprising:
- subjecting a quantity of the powder material to uniaxial compression;
- collecting compaction data during the step of subjecting;
- and
- fitting the collected data to a model.
A system for assessing a powder material, the system comprising:
- a compression device operable to subject a quantity of the powder material to uniaxial compression and collect corresponding compaction data;
- and
- an assessment device programmed to fit the collected data to a model.
Dependencies are inferred from the claim text.