US 2026/0275359 A1 · NANO-PERFORATOR HAVING IMPROVED ANTI-VIRAL ACTIVITY

Abstract

The present invention relates to improvement in the prevention and treatment of viral infectious diseases through the structural modification or improvement of a nano-perforator. According to the present invention, a nano-perforator, having modified structure, area, shape and membrane scaffold protein characteristics, has improved thermal stability and has maximized anti-viral activity through an increase in the efficiency of perforation activity, an increase in the stability of nano-perforator and the provision of virus specificity, and thus can be usable as a pharmaceutical composition for preventing or treating viral infectious diseases.

Claims14

Dependent claims

A method of treating a viral infection in a subject in need thereof, the method comprising administering to the subject a nanoperforator comprising:

a lipid bilayer nanodisc formed of a phospholipid;
and
a membrane scaffold protein (MSP) surrounding an outer circumferential surface of the lipid bilayer nanodisc,
wherein the nanoperforator further comprises a receptor for a surface antigen of a virus.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

19/575,865Filed 23 Mar 2026

Priority

KR 10-2019-011717724 Sep 2019

Published

17 Sep 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification15 codes

A61P 31/14
Antivirals: for RNA viruses
C12N 15/62
DNA or RNA fragments; Modified forms thereof ; Non-coding nucleic acids having a biological activity: dNA sequences coding for fusion proteins
A61P 31/22
For DNA viruses: for herpes viruses
C07K 14/47
From vertebrates: from mammals

Nano-perforator having improved anti-viral activity

Life of this patent

Nano-perforator having improved anti-viral activity

Life of this patent

Abstract

Claims14