Chemically modified antisense oligonucleotides for use in rna editing

An antisense oligonucleotide (AON) that is able to mediate deamination of a target adenosine in a cell by recruitment of an endogenous ADAR enzyme after the AON has formed a double-stranded complex with a region of a target RNA nucleic acid molecule in the cell, wherein the region comprises the target adenosine, wherein the ADAR enzyme can deaminate the target adenosine into an inosine, and wherein the AON comprises one or more linkage modifications with a structure according to formula (I):

• wherein:
• X=O or S;
• and R=an aryl, a substituted aryl, a heterocycle, a substituted heterocycle, an aromatic heterocycle, a substituted aromatic heterocycle, a C1-C6 alkoxy, a substituted C1-C6 alkoxy, a C1-C20 alkyl, a substituted C1-C20 alkyl, a C1—C alkenyl, a C1-C6 substituted alkenyl, a C1-C6 alkynyl, a substituted C1-C6 alkynyl, or a conjugate group.