US 2026/0275299 A1 · Bioprinted Three-Dimensional Tumor Model

Bioprinted Three-Dimensional Tumor Model

AssigneesAsociacióN Centro De InvestigacióN En Biomateriales - Cic Biomagune, AdministracióN General Comunidad AutóNoma De Euskadi

InventorsPatricia GONZÁLEZ CALLEJO, Paula VÁZQUEZ ARISTIZABAL, Luis Manuel LIZ-MARZÁN, Ander IZETA PERMISÁN, Dorleta JIMENEZ DE ABERASTURI ARRANZ, Malou HENRIKSEN-LACEY, Clara GARCÍA ASTRAIN

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Abstract

The present invention relates a bioprinted three-dimensional tumor model which is able to reproduce the cellular heterogeneity, the spatial architecture, and the tissue-specific ECM of the tumor microenvironment. In addition, the invention refers to a process for preparing such three-dimensional tumor model, to methods for testing anticancer drugs as well as to the use of the tumor model in developing personalized medicine and developing new therapies based on the understanding of the in vitro tumor progression.

Claims15

Dependent claims

A bioprinted three-dimensional tumor model comprising:

a) An inner core comprising tumor cells;
and
b) an outer stromal shell comprising fibroblasts and/or endothelial cells completely surrounding the core;
wherein the cells from the core and the stromal shell are embedded in a decellularized extracellular matrix (dECM).

1 more element

Dependencies are inferred from the claim text.