Allogeneic and xenogeneic subcutaneous adipose tissue and methods for preserving same
AssigneeSinUse Corp.
InventorsGabriel Zada, Seyed Mohammadreza Ghodsi
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Abstract
Disclosed herein are embodiments of a processed allogeneic and xenogeneic subcutaneous adipose tissue for reconstruction and cosmetic surgeries and method for preparing allogeneic and xenogeneic subcutaneous adipose tissue for reconstruction and cosmetic surgeries. The preservation method can include the subcutaneous adipose tissue being subjected to a set of physiochemical treatments to prohibit host immunogenic response upon transplantation/implantation.
Claims49
A processed adipose tissue, comprising:
- an adipose tissue extracted from a human or animal donor, the adipose tissue processed such that cells are removed from the tissue;
- and
- wherein the adipose tissue contains collagen, elastin, fibrin, lipids and extracellular matrix.
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A method of processing a subcutaneous adipose tissue comprising application of a set of treatments to an intact adipose tissue from a donor/cadaver, the set of treatments comprising:
- receiving an adipose tissue;
- trimming vasculatures, skin, and fascia from the adipose tissue;
- incubating the adipose tissue in a buffer solution;
- thawing the frozen adipose tissue using a cryogenic solution;
- incubating the adipose tissue in a digestion solution;
- incubating the adipose tissue in a concentrated ionic solution overnight;
- extracting polar cellular components from the adipose tissue;
- incubating the adipose tissue in a non-ionic surfactant solutions;
- and
- washing the subcutaneous adipose tissue in ethanol or IPA or methanol;
- whereby the subcutaneous adipose tissue is made.
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A method of preserving a subcutaneous adipose tissue for cosmetic and reconstruction surgeries comprising:
- receiving an adipose tissue;
- trimming vasculatures, skin, and fascia from the adipose tissue;
- incubating the adipose tissue in a buffer solution until freezing;
- thawing the frozen adipose tissue using a cryogenic solution;
- incubating the adipose tissue in a digestion solution;
- incubating the adipose tissue in a concentrated ionic solution;
- extracting polar cellular components from the adipose tissue;
- incubating the subcutaneous adipose tissue in a non-ionic surfactant solutions;
- washing the subcutaneous adipose tissue in ethanol or IPA or methanol;
- wherein the adipose tissue is processed;
- sterilizing the processed adipose tissue;
- incubating the adipose tissue in an anti-inflammatory/antibiotics cocktail and sucrose and dextran solution;
- packaging the sterilized adipose tissue in a vacuum-sealed plastic container;
- and
- storing the sterilized adipose tissue.
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Dependencies are inferred from the claim text.