Use of chimera in targeted protein degradation technology
AssigneeSun Yat-Sen University
InventorsXiaoqing CAI, Xianxing JIANG
Life of this patent
Estimating the term…
Abstract
Disclosed is the use of a chimera in a targeted protein degradation technique. The chimera comprises a molecule that selectively binds to a protein of interest and a signal sequence that is directly or indirectly linked to the molecule and mediates the transport of the protein of interest to a lysosome. By constructing a signal-mediated lysosome-targeted chimera, a lysosome-targeted structural unit is used to promote endocytosis, so as to finally realize the enrichment and degradation of the chimera bound protein of interest in the lysosome.
Claims39
-18. (canceled)
A method for targeted protein degradation, characterized in that the method comprises administering to a subject an effective amount of a chimera, the chimera comprising:
- (1) a molecule selectively binding to a protein of interest;
- and
- (2) a signal sequence mediating the transport of the protein of interest to the lysosome, which is directly or indirectly fused to the molecule.
A chimera, comprising:
- (1) a molecule selectively binding to a protein of interest;
- and
- (2) a signal sequence mediating the transport of the protein of interest to the lysosome, which is directly or indirectly fused to the molecule.
Dependencies are inferred from the claim text.