Anti-mullerian hormone receptor binding peptides
AssigneeOvares D LLC
InventorLaura Detti
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AssigneeOvares D LLC
InventorLaura Detti
Estimating the term…
Disclosed are compositions and methods including Anti-Müllerian Hormone (AMH) receptor binding peptides. The AMH receptor binding peptides can be used, for example, to modify the activity of the AMH receptor. For example, the AMH receptor binding peptides can activate the AMH receptor, such as the AMH receptor 2, thereby mimicking the function of AMH. In other examples, the AMH receptor binding peptides function as AMH receptor antagonists, thereby interfering with the function of endogenous AMH. By modifying the activity of the AMH receptor, the peptides have multiple applications, including for example modification of treatment of precocious puberty in females, delay of natural menopause, preservation of ovarian follicular reserve, contraception, fertility preservation after ovarian cortex transplant, treatment of endometriosis, treatment of cancer and/or cancer prevention, and treatment of polycystic ovary syndrome (PCOS).
A method for activating anti-Mullerian hormone receptor 2 (AMH-R2) in a subject, the method comprising administering to the subject an effective amount of an AMH-R2 binding peptide,
A method of modulating folliculogenesis in a subject, the method comprising administering to the subject an effective amount of an AMH-R2 binding peptide,
A method of inhibiting premature follicle activation in a subject undergoing ovarian tissue transplantation or whole ovary transplantation, the method comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising an AMH-R2 binding peptide, wherein the AMH-R2 binding peptide comprises:
Dependencies are inferred from the claim text.