US 2026/0274968 A1 · METHODS OF USING IL-18 FUSION PROTEINS

Abstract

Described herein are method of using fusion proteins composed of elements such as one or more proteins/polypeptides capable of translocating into an endoplasmic reticulum (ER) and an interleukin 18 (IL-18) or a fragment or variant of IL-18. The proteins/polypeptides capable of translocating into the ER include but are not limited to an immunoglobular protein such as Fc region, VHH antibody, and scFv, and a globular protein such as serum albumin. The IL-18 may be a precursor IL-18 that resembles the natural pro-cytokine in which IL-18 is fused to the C-terminus of its propeptide or a propeptide variant. These fusion proteins can be used in methods of treating cancer or fibrosis by activating an IL-18 receptor complex (RC) signal on a cell, releasing or exposing mature IL-18 in a tumor microenviromnent or adjacent to a tumor and/or increasing memory CD8+ T cell proliferation.

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Methods of using il-18 fusion proteins

Life of this patent

Methods of using il-18 fusion proteins

Life of this patent

Abstract

Claims80