US 2026/0274947 A1Published application

Humanized monoclonal antibodies and methods of use for the diagnosis and treatment of colon and pancreas cancer

AssigneePrecision Biologics, Inc.

InventorsXue-Ping WANG, Philip M. ARLEN

Life of this patent

Estimating the term…

Abstract

This invention relates to humanized antibodies that selectively bind the 31.1 epitope on the A33 protein differentially expressed in cancers including, lung cancer, ovarian cancer, pancreas cancer, breast cancer, and colon cancer, and diagnostic and therapeutic usages.

Claims2

Dependent claims

An isolated antibody that binds to an A33 antigen, or a fragment thereof, comprising:

a) at least one heavy chain sequence comprising the amino acid sequence of SEQ ID NO:74, 75, 76, or 77 or one of the variable regions contained therein;
b) at least one heavy chain CDR sequence comprising at least one amino acid sequence of SEQ ID NO:
78, 79, 80, 81, 82, or 83;
c) at least one light chain sequence comprising the amino acid sequence of SEQ ID NO:84, 85, 86, 87;
d) at least one light chain CDR sequence comprising at least one amino acid sequence of SEQ ID NO:
88, 89, 90, 91, 92, or 93;
e) a heavy chain comprising the amino acid sequence of SEQ ID NO:74 and the light chain amino acid sequence of SEQ ID NO:84;
f) a heavy chain comprising the amino acid sequence of SEQ ID NO:75 and the light chain amino acid sequence of SEQ ID NO:85;
g) a heavy chain comprising the amino acid sequence of SEQ ID NO:76 and the light chain amino acid sequence of SEQ ID NO:86;
h) a heavy chain comprising the amino acid sequence of SEQ ID NO:77 and the light chain amino acid sequence of SEQ ID NO:87;
i) a heavy chain comprising the CDR1 amino acid sequence of SEQ ID NO:78, the CDR2 amino acid sequence of SEQ ID NO:79, 80, 81, or 82 and the CDR3 amino acid sequence of SEQ ID NO:83;
j) a heavy chain comprising the CDR1 amino acid sequence of SEQ ID NO:78, the CDR2 amino acid sequence of SEQ ID NO:79, and the CDR3 amino acid sequence of SEQ ID NO:83;
k) a heavy chain comprising the CDR1 amino acid sequence of SEQ ID NO:78, the CDR2 amino acid sequence of SEQ ID NO:80 and the CDR3 amino acid sequence of SEQ ID NO:83;
l) a heavy chain comprising the CDR1 amino acid sequence of SEQ ID NO:78, the CDR2 amino acid sequence of SEQ ID NO:81 and the CDR3 amino acid sequence of SEQ ID NO:83;
m) a heavy chain comprising the CDR1 amino acid sequence of SEQ ID NO:78, the CDR2 amino acid sequence of SEQ ID NO:82 and the CDR3 amino acid sequence of SEQ ID NO:83;
n) a light chain comprising the CDR1 amino acid sequence of SEQ ID NO:88, 89, or 90, the CDR2 amino acid sequence of SEQ ID NO:91 or 92 and the CDR3 amino acid sequence of SEQ ID NO:
93;
o) a light chain comprising the CDR1 amino acid sequence of SEQ ID NO:88, the CDR2 amino acid sequence of SEQ ID NO:91 and the CDR3 amino acid sequence of SEQ ID NO:93;
p) a light chain comprising the CDR1 amino acid sequence of SEQ ID NO:89, the CDR2 amino acid sequence of SEQ ID NO:91 and the CDR3 amino acid sequence of SEQ ID NO:93;
q) a light chain comprising the CDR1 amino acid sequence of SEQ ID NO:90, the CDR2 amino acid sequence of SEQ ID NO:91 and the CDR3 amino acid sequence of SEQ ID NO:93;
r) a light chain comprising the CDR1 amino acid sequence of SEQ ID NO:88, the CDR2 amino acid sequence of SEQ ID NO:92 and the CDR3 amino acid sequence of SEQ ID NO:93;
s) a light chain comprising the CDR1 amino acid sequence of SEQ ID NO:89, the CDR2 amino acid sequence of SEQ ID NO:92 and the CDR3 amino acid sequence of SEQ ID NO:93;
t) a light chain comprising the CDR1 amino acid sequence of SEQ ID NO:90, the CDR2 amino acid sequence of SEQ ID NO:92 and the CDR3 amino acid sequence of SEQ ID NO:93;
u) a heavy chain comprising the CDR1 amino acid sequence of SEQ ID NO:78, the CDR2 amino acid sequence of SEQ ID NO:79, 80, 81, or 82 and the CDR3 amino acid sequence of SEQ ID NO:83 and a light chain comprising the CDR1 amino acid sequence of SEQ ID NO:88, 89, or 90, the CDR2 amino acid sequence of SEQ ID NO:91 or 92 and the CDR3 amino acid sequence of SEQ ID NO:93;
v) a heavy chain comprising the CDRs contained in antibody cdr31.1-HC (SEQ ID NO:74) and a light chain comprising the CDRs contained in antibody cdr31.1-LC (SEQ ID NO:84);
w) a heavy chain comprising the CDRs contained in antibody cdr31.1-HC (SEQ ID NO:74) and a light chain comprising the CDRs contained in antibody abb31.1-LC (SEQ ID NO:85);
x) a heavy chain comprising the CDRs contained in antibody cdr31.1-HC (SEQ ID NO:74) and a light chain comprising the CDRs contained in antibody sdr3 1.1-LC (SEQ ID NO:86);
y) a heavy chain comprising the CDRs contained in antibody cdr3 1.1-HC (SEQ ID NO:74) and a light chain comprising the CDRs contained in antibody ven31.1-LC (SEQ ID NO:87);
z) a heavy chain comprising the CDRs contained in antibody abb31.1-HC (SEQ ID NO:75) and a light chain comprising the CDRs contained in antibody cdr3 1.1-LC (SEQ ID NO:84);
aa) a heavy chain comprising the CDRs contained in antibody abb3 1.1-HC (SEQ ID NO:75) and a light chain comprising the CDRs contained in antibody abb31.1-LC (SEQ ID NO:85);
bb) a heavy chain comprising the CDRs contained in antibody abb31.1-HC (SEQ ID NO:75) and a light chain comprising the CDRs contained in antibody sdr31.1-L C (SEQ ID NO:86);
cc) a heavy chain comprising the CDRs contained in antibody abb3 1.1-HC (SEQ ID NO:75) and a light chain comprising the CDRs contained in antibody ven31.1-LC (SEQ ID NO:87);
dd) a heavy chain comprising the CDRs contained in antibody sdr31.1-HC (SEQ ID NO:76) and a light chain comprising the CDRs contained in antibody cdr31.1-LC (SEQ ID NO:84);
ee) a heavy chain comprising the CDRs contained in antibody sdr31.1-HC (SEQ ID NO:76) and a light chain comprising the CDRs contained in antibody abb3 1.1-LC (SEQ ID NO:85);
ff) a heavy chain comprising the CDRs contained in antibody sdr31.1-HC (SEQ ID NO:76) and a light chain comprising the CDRs contained in antibody sdr31.1-LC (SEQ ID NO:
86);
gg) a heavy chain comprising the CDRs contained in antibody sdr31.1-HC (SEQ ID NO:76) and a light chain comprising the CDRs contained in antibody ven31.1-LC (SEQ ID NO:87);
hh) a heavy chain comprising the CDRs contained in antibody ven31.1-HC (SEQ ID NO:77) and a light chain comprising the CDRs contained in antibody cdr31.1-LC (SEQ ID NO:84);
ii) a heavy chain comprising the CDRs contained in antibody ven31.1-HC (SEQ ID NO:77) and a light chain comprising the CDRs contained in antibody abb31.1-LC (SEQ ID NO:85);
jj) a heavy chain comprising the CDRs contained in antibody ven31.1-HC (SEQ ID NO:77) and a light chain comprising the CDRs contained in antibody sdr31.1-LC (SEQ ID NO:86);
kk) a heavy chain comprising the CDRs contained in antibody ven31.1-HC (SEQ ID NO:77) and a light chain comprising the CDRs contained in antibody ven31.1-LC (SEQ ID NO:87);
ll) a heavy chain comprising the variable chain of antibody cdr31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:74) and a light chain comprising the variable light chain of antibody cdr31.1-LC (amino acids 1 to 107 of SEQ ID NO:84);
mm) a heavy chain comprising the variable chain of antibody cdr31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:74) and a light chain comprising the variable light chain of antibody abb31.1-LC (amino acids 1 to 107 of SEQ ID NO:85);
nn) a heavy chain comprising the variable chain of antibody cdr31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:74) and a light chain comprising the variable light chain of antibody sdr31.1-LC (amino acids 1 to 107 of SEQ ID NO:
86);
oo) a heavy chain comprising the variable chain of antibody cdr31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:74) and a light chain comprising the variable light chain of antibody ven31.1-LC (amino acids 1 to 107 of SEQ ID NO:87);
pp) a heavy chain comprising the variable chain of antibody abb31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:75) and a light chain comprising the variable light chain of antibody cdr31.1-LC (amino acids 1 to 107 of SEQ ID NO:84);
qq) a heavy chain comprising the variable chain of antibody abb31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:75) and a light chain comprising the variable light chain of antibody abb31.1-L C (amino acids 1 to 107 of SEQ ID NO:85);
rr) a heavy chain comprising the variable chain of antibody abb31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:75) and a light chain comprising the variable light chain of antibody sdr31.1-LC (amino acids 1 to 107 of SEQ ID NO:86);
ss) a heavy chain comprising the variable chain of antibody abb3 1.1-HC (amino acids 1 to 1 18 of SEQ ID NO:75) and a light chain comprising the variable light chain of antibody ven31.1-LC (amino acids 1 to 107 of SEQ ID NO:87);
tt) a heavy chain comprising the variable chain of antibody sdr31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:76) and a light chain comprising the variable light chain of antibody cdr31. 1-LC (amino acids 1 to 107 of SEQ ID NO:84);
uu) a heavy chain comprising the variable chain of antibody sdr31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:76) and a light chain comprising the variable light chain of antibody abb31.1-LC (amino acids 1 to 107 of SEQ ID NO:85);
vv) a heavy chain comprising the variable chain of antibody sdr31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:76) and a light chain comprising the variable light chain of antibody sdr31.1-LC (amino acids 1 to 107 of SEQ ID NO:86);
ww) a heavy chain comprising the variable chain of antibody sdr31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:76) and a light chain comprising the variable light chain of antibody ven31.1-LC (amino acids 1 to 107 of SEQ ID NO:87);
xx) a heavy chain comprising the variable chain of antibody ven31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:77) and a light chain comprising the variable light chain of antibody cdr31.1-LC (amino acids 1 to 107 of SEQ ID NO:84);
yy) a heavy chain comprising the variable chain of antibody ven31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:77) and a light chain comprising the variable light chain of antibody abb31.1-LC (amino acids 1 to 107 of SEQ ID NO:85);
zz) a heavy chain comprising the variable chain of antibody ven31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:77) and a light chain comprising the variable light chain of antibody sdr31.1-LC (amino acids 1 to 107 of SEQ ID NO:86);
aaa) a heavy chain comprising the variable chain of antibody ven31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:77) and a light chain comprising the variable light chain of antibody ven31.1-LC (amino acids 1 to 107 of SEQ ID NO:87);
bbb) a heavy chain polypeptide of antibody cdr31.1-HC (SEQ ID NO:74) and a light chain polypeptide of antibody cdr3 1.1-LC (SEQ ID NO:
84);
ccc) a heavy chain polypeptide of antibody cdr31.1-HC (SEQ ID NO:74) and a light chain polypeptide of antibody abb31.1-LC (SEQ ID NO:85);
ddd) a heavy chain polypeptide of antibody cdr31.1-HC (SEQ ID NO:74) and a light chain polypeptide of antibody sdr31.1-LC (SEQ ID NO:86);
eee) a heavy chain polypeptide of antibody cdr31. 1-HC (SEQ ID NO:74) and a light chain polypeptide of antibody ven3 1. 1-LC (SEQ ID NO:87);
fff) a heavy chain polypeptide of antibody abb31.1-HC (SEQ ID NO:75) and a light chain polypeptide of antibody cdr31.1-LC (SEQ ID NO:84);
ggg) a heavy chain polypeptide of antibody abb31.1-HC (SEQ ID NO:75) and a light chain polypeptide of antibody abb31.1-LC (SEQ ID NO:
85);
hhh) a heavy chain polypeptide of antibody abb3 1.1-HC (SEQ ID NO:75) and a light chain polypeptide of antibody sdr31.1-LC (SEQ ID NO:
86);
iii) a heavy chain polypeptide of antibody abb31.1-HC (SEQ ID NO:75) and a light chain polypeptide of antibody ven31.1-LC (SEQ ID NO:87);
jjj) a heavy chain polypeptide of antibody sdr3 1.1-HC (SEQ ID NO:76) and a light chain polypeptide of antibody cdr31.1-LC (SEQ ID NO:84);
kkk) a heavy chain polypeptide of antibody sdr31.1-HC (SEQ ID NO:76) and a light chain polypeptide of antibody abb31.1-L C (SEQ ID NO:85);
lll) a heavy chain polypeptide of antibody sdr31.1-HC (SEQ ID NO:76) and a light chain polypeptide of antibody sdr31.1-LC (SEQ ID NO:
86);
mmm) a heavy chain polypeptide of antibody sdr3 1.1-HC (SEQ ID NO:76) and a light chain polypeptide of antibody ven31.1-LC (SEQ ID NO:87);
nnn) a heavy chain polypeptide of antibody ven31.1-HC (SEQ ID NO:77) and a light chain polypeptide of antibody cdr31.1-LC (SEQ ID NO:84);
ooo) a heavy chain polypeptide of antibody ven3 1.1-HC (SEQ ID NO:77) and a light chain polypeptide of antibody abb31.1-L C (SEQ ID NO:85);
ppp) a heavy chain polypeptide of antibody ven31.1-HC (SEQ ID NO:77) and a light chain polypeptide of antibody sdr31.1-LC (SEQ ID NO:86);
or
qqq) a heavy chain polypeptide of antibody ven31.1-HC (SEQ ID NO:77) and a light chain polypeptide of antibody ven31.1-LC (SEQ ID NO:
87).

77 more elements

Dependencies are inferred from the claim text.

Facts

Application: 19/574,885Filed 23 Mar 2026
Priority: 28 Dec 2012
Published: 17 Sep 2026
Term ends: Not estimatedThe source records don’t support an estimate.

Classification21 codes

C07K 16/2806
Against the immunoglobulin superfamily: against CD2
A61K 39/3955
Against materials from animals: against proteinaceous materials, e.g. enzymes, hormones, lymphokines
A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…
A61P 35/00
Antineoplastic agents

Family

Application61/747,067Us provisional application · filed 28 Dec 2012
Application14/655,982Division · filed 30 Dec 2013
Application15/934,526Division · filed 23 Mar 2018
Application16/874,826Division · filed 15 May 2020
Application18/048,270Division · filed 20 Oct 2022
Application19/574,885Division
US 10,689,443 B2Related patent
US 11,505,604 B2Related patent
US 12,606,621 B2Related patent
US 2016/0194398 A1Published application
US 2018/0265583 A1Published application
US 2021/0002368 A1Published application
US 2023/0295298 A1Published application
US 9,938,344 B2Related patent
US 2026/0274947 A1This patent

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Abstract

An isolated antibody that binds to an A33 antigen, or a fragment thereof, comprising:

a) at least one heavy chain sequence comprising the amino acid sequence of SEQ ID NO:74, 75, 76, or 77 or one of the variable regions contained therein;
b) at least one heavy chain CDR sequence comprising at least one amino acid sequence of SEQ ID NO:
78, 79, 80, 81, 82, or 83;
c) at least one light chain sequence comprising the amino acid sequence of SEQ ID NO:84, 85, 86, 87;
d) at least one light chain CDR sequence comprising at least one amino acid sequence of SEQ ID NO:
88, 89, 90, 91, 92, or 93;
e) a heavy chain comprising the amino acid sequence of SEQ ID NO:74 and the light chain amino acid sequence of SEQ ID NO:84;
f) a heavy chain comprising the amino acid sequence of SEQ ID NO:75 and the light chain amino acid sequence of SEQ ID NO:85;
g) a heavy chain comprising the amino acid sequence of SEQ ID NO:76 and the light chain amino acid sequence of SEQ ID NO:86;
h) a heavy chain comprising the amino acid sequence of SEQ ID NO:77 and the light chain amino acid sequence of SEQ ID NO:87;
i) a heavy chain comprising the CDR1 amino acid sequence of SEQ ID NO:78, the CDR2 amino acid sequence of SEQ ID NO:79, 80, 81, or 82 and the CDR3 amino acid sequence of SEQ ID NO:83;
j) a heavy chain comprising the CDR1 amino acid sequence of SEQ ID NO:78, the CDR2 amino acid sequence of SEQ ID NO:79, and the CDR3 amino acid sequence of SEQ ID NO:83;
k) a heavy chain comprising the CDR1 amino acid sequence of SEQ ID NO:78, the CDR2 amino acid sequence of SEQ ID NO:80 and the CDR3 amino acid sequence of SEQ ID NO:83;
l) a heavy chain comprising the CDR1 amino acid sequence of SEQ ID NO:78, the CDR2 amino acid sequence of SEQ ID NO:81 and the CDR3 amino acid sequence of SEQ ID NO:83;
m) a heavy chain comprising the CDR1 amino acid sequence of SEQ ID NO:78, the CDR2 amino acid sequence of SEQ ID NO:82 and the CDR3 amino acid sequence of SEQ ID NO:83;
n) a light chain comprising the CDR1 amino acid sequence of SEQ ID NO:88, 89, or 90, the CDR2 amino acid sequence of SEQ ID NO:91 or 92 and the CDR3 amino acid sequence of SEQ ID NO:
93;
o) a light chain comprising the CDR1 amino acid sequence of SEQ ID NO:88, the CDR2 amino acid sequence of SEQ ID NO:91 and the CDR3 amino acid sequence of SEQ ID NO:93;
p) a light chain comprising the CDR1 amino acid sequence of SEQ ID NO:89, the CDR2 amino acid sequence of SEQ ID NO:91 and the CDR3 amino acid sequence of SEQ ID NO:93;
q) a light chain comprising the CDR1 amino acid sequence of SEQ ID NO:90, the CDR2 amino acid sequence of SEQ ID NO:91 and the CDR3 amino acid sequence of SEQ ID NO:93;
r) a light chain comprising the CDR1 amino acid sequence of SEQ ID NO:88, the CDR2 amino acid sequence of SEQ ID NO:92 and the CDR3 amino acid sequence of SEQ ID NO:93;
s) a light chain comprising the CDR1 amino acid sequence of SEQ ID NO:89, the CDR2 amino acid sequence of SEQ ID NO:92 and the CDR3 amino acid sequence of SEQ ID NO:93;
t) a light chain comprising the CDR1 amino acid sequence of SEQ ID NO:90, the CDR2 amino acid sequence of SEQ ID NO:92 and the CDR3 amino acid sequence of SEQ ID NO:93;
u) a heavy chain comprising the CDR1 amino acid sequence of SEQ ID NO:78, the CDR2 amino acid sequence of SEQ ID NO:79, 80, 81, or 82 and the CDR3 amino acid sequence of SEQ ID NO:83 and a light chain comprising the CDR1 amino acid sequence of SEQ ID NO:88, 89, or 90, the CDR2 amino acid sequence of SEQ ID NO:91 or 92 and the CDR3 amino acid sequence of SEQ ID NO:93;
v) a heavy chain comprising the CDRs contained in antibody cdr31.1-HC (SEQ ID NO:74) and a light chain comprising the CDRs contained in antibody cdr31.1-LC (SEQ ID NO:84);
w) a heavy chain comprising the CDRs contained in antibody cdr31.1-HC (SEQ ID NO:74) and a light chain comprising the CDRs contained in antibody abb31.1-LC (SEQ ID NO:85);
x) a heavy chain comprising the CDRs contained in antibody cdr31.1-HC (SEQ ID NO:74) and a light chain comprising the CDRs contained in antibody sdr3 1.1-LC (SEQ ID NO:86);
y) a heavy chain comprising the CDRs contained in antibody cdr3 1.1-HC (SEQ ID NO:74) and a light chain comprising the CDRs contained in antibody ven31.1-LC (SEQ ID NO:87);
z) a heavy chain comprising the CDRs contained in antibody abb31.1-HC (SEQ ID NO:75) and a light chain comprising the CDRs contained in antibody cdr3 1.1-LC (SEQ ID NO:84);
aa) a heavy chain comprising the CDRs contained in antibody abb3 1.1-HC (SEQ ID NO:75) and a light chain comprising the CDRs contained in antibody abb31.1-LC (SEQ ID NO:85);
bb) a heavy chain comprising the CDRs contained in antibody abb31.1-HC (SEQ ID NO:75) and a light chain comprising the CDRs contained in antibody sdr31.1-L C (SEQ ID NO:86);
cc) a heavy chain comprising the CDRs contained in antibody abb3 1.1-HC (SEQ ID NO:75) and a light chain comprising the CDRs contained in antibody ven31.1-LC (SEQ ID NO:87);
dd) a heavy chain comprising the CDRs contained in antibody sdr31.1-HC (SEQ ID NO:76) and a light chain comprising the CDRs contained in antibody cdr31.1-LC (SEQ ID NO:84);
ee) a heavy chain comprising the CDRs contained in antibody sdr31.1-HC (SEQ ID NO:76) and a light chain comprising the CDRs contained in antibody abb3 1.1-LC (SEQ ID NO:85);
ff) a heavy chain comprising the CDRs contained in antibody sdr31.1-HC (SEQ ID NO:76) and a light chain comprising the CDRs contained in antibody sdr31.1-LC (SEQ ID NO:
86);
gg) a heavy chain comprising the CDRs contained in antibody sdr31.1-HC (SEQ ID NO:76) and a light chain comprising the CDRs contained in antibody ven31.1-LC (SEQ ID NO:87);
hh) a heavy chain comprising the CDRs contained in antibody ven31.1-HC (SEQ ID NO:77) and a light chain comprising the CDRs contained in antibody cdr31.1-LC (SEQ ID NO:84);
ii) a heavy chain comprising the CDRs contained in antibody ven31.1-HC (SEQ ID NO:77) and a light chain comprising the CDRs contained in antibody abb31.1-LC (SEQ ID NO:85);
jj) a heavy chain comprising the CDRs contained in antibody ven31.1-HC (SEQ ID NO:77) and a light chain comprising the CDRs contained in antibody sdr31.1-LC (SEQ ID NO:86);
kk) a heavy chain comprising the CDRs contained in antibody ven31.1-HC (SEQ ID NO:77) and a light chain comprising the CDRs contained in antibody ven31.1-LC (SEQ ID NO:87);
ll) a heavy chain comprising the variable chain of antibody cdr31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:74) and a light chain comprising the variable light chain of antibody cdr31.1-LC (amino acids 1 to 107 of SEQ ID NO:84);
mm) a heavy chain comprising the variable chain of antibody cdr31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:74) and a light chain comprising the variable light chain of antibody abb31.1-LC (amino acids 1 to 107 of SEQ ID NO:85);
nn) a heavy chain comprising the variable chain of antibody cdr31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:74) and a light chain comprising the variable light chain of antibody sdr31.1-LC (amino acids 1 to 107 of SEQ ID NO:
86);
oo) a heavy chain comprising the variable chain of antibody cdr31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:74) and a light chain comprising the variable light chain of antibody ven31.1-LC (amino acids 1 to 107 of SEQ ID NO:87);
pp) a heavy chain comprising the variable chain of antibody abb31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:75) and a light chain comprising the variable light chain of antibody cdr31.1-LC (amino acids 1 to 107 of SEQ ID NO:84);
qq) a heavy chain comprising the variable chain of antibody abb31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:75) and a light chain comprising the variable light chain of antibody abb31.1-L C (amino acids 1 to 107 of SEQ ID NO:85);
rr) a heavy chain comprising the variable chain of antibody abb31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:75) and a light chain comprising the variable light chain of antibody sdr31.1-LC (amino acids 1 to 107 of SEQ ID NO:86);
ss) a heavy chain comprising the variable chain of antibody abb3 1.1-HC (amino acids 1 to 1 18 of SEQ ID NO:75) and a light chain comprising the variable light chain of antibody ven31.1-LC (amino acids 1 to 107 of SEQ ID NO:87);
tt) a heavy chain comprising the variable chain of antibody sdr31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:76) and a light chain comprising the variable light chain of antibody cdr31. 1-LC (amino acids 1 to 107 of SEQ ID NO:84);
uu) a heavy chain comprising the variable chain of antibody sdr31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:76) and a light chain comprising the variable light chain of antibody abb31.1-LC (amino acids 1 to 107 of SEQ ID NO:85);
vv) a heavy chain comprising the variable chain of antibody sdr31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:76) and a light chain comprising the variable light chain of antibody sdr31.1-LC (amino acids 1 to 107 of SEQ ID NO:86);
ww) a heavy chain comprising the variable chain of antibody sdr31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:76) and a light chain comprising the variable light chain of antibody ven31.1-LC (amino acids 1 to 107 of SEQ ID NO:87);
xx) a heavy chain comprising the variable chain of antibody ven31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:77) and a light chain comprising the variable light chain of antibody cdr31.1-LC (amino acids 1 to 107 of SEQ ID NO:84);
yy) a heavy chain comprising the variable chain of antibody ven31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:77) and a light chain comprising the variable light chain of antibody abb31.1-LC (amino acids 1 to 107 of SEQ ID NO:85);
zz) a heavy chain comprising the variable chain of antibody ven31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:77) and a light chain comprising the variable light chain of antibody sdr31.1-LC (amino acids 1 to 107 of SEQ ID NO:86);
aaa) a heavy chain comprising the variable chain of antibody ven31.1-HC (amino acids 1 to 1 18 of SEQ ID NO:77) and a light chain comprising the variable light chain of antibody ven31.1-LC (amino acids 1 to 107 of SEQ ID NO:87);
bbb) a heavy chain polypeptide of antibody cdr31.1-HC (SEQ ID NO:74) and a light chain polypeptide of antibody cdr3 1.1-LC (SEQ ID NO:
84);
ccc) a heavy chain polypeptide of antibody cdr31.1-HC (SEQ ID NO:74) and a light chain polypeptide of antibody abb31.1-LC (SEQ ID NO:85);
ddd) a heavy chain polypeptide of antibody cdr31.1-HC (SEQ ID NO:74) and a light chain polypeptide of antibody sdr31.1-LC (SEQ ID NO:86);
eee) a heavy chain polypeptide of antibody cdr31. 1-HC (SEQ ID NO:74) and a light chain polypeptide of antibody ven3 1. 1-LC (SEQ ID NO:87);
fff) a heavy chain polypeptide of antibody abb31.1-HC (SEQ ID NO:75) and a light chain polypeptide of antibody cdr31.1-LC (SEQ ID NO:84);
ggg) a heavy chain polypeptide of antibody abb31.1-HC (SEQ ID NO:75) and a light chain polypeptide of antibody abb31.1-LC (SEQ ID NO:
85);
hhh) a heavy chain polypeptide of antibody abb3 1.1-HC (SEQ ID NO:75) and a light chain polypeptide of antibody sdr31.1-LC (SEQ ID NO:
86);
iii) a heavy chain polypeptide of antibody abb31.1-HC (SEQ ID NO:75) and a light chain polypeptide of antibody ven31.1-LC (SEQ ID NO:87);
jjj) a heavy chain polypeptide of antibody sdr3 1.1-HC (SEQ ID NO:76) and a light chain polypeptide of antibody cdr31.1-LC (SEQ ID NO:84);
kkk) a heavy chain polypeptide of antibody sdr31.1-HC (SEQ ID NO:76) and a light chain polypeptide of antibody abb31.1-L C (SEQ ID NO:85);
lll) a heavy chain polypeptide of antibody sdr31.1-HC (SEQ ID NO:76) and a light chain polypeptide of antibody sdr31.1-LC (SEQ ID NO:
86);
mmm) a heavy chain polypeptide of antibody sdr3 1.1-HC (SEQ ID NO:76) and a light chain polypeptide of antibody ven31.1-LC (SEQ ID NO:87);
nnn) a heavy chain polypeptide of antibody ven31.1-HC (SEQ ID NO:77) and a light chain polypeptide of antibody cdr31.1-LC (SEQ ID NO:84);
ooo) a heavy chain polypeptide of antibody ven3 1.1-HC (SEQ ID NO:77) and a light chain polypeptide of antibody abb31.1-L C (SEQ ID NO:85);
ppp) a heavy chain polypeptide of antibody ven31.1-HC (SEQ ID NO:77) and a light chain polypeptide of antibody sdr31.1-LC (SEQ ID NO:86);
or
qqq) a heavy chain polypeptide of antibody ven31.1-HC (SEQ ID NO:77) and a light chain polypeptide of antibody ven31.1-LC (SEQ ID NO:
87).

77 more elements

Facts

Application

19/574,885Filed 23 Mar 2026

Priority

28 Dec 2012

Published

17 Sep 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification21 codes

C07K 16/2806
Against the immunoglobulin superfamily: against CD2
A61K 39/3955
Against materials from animals: against proteinaceous materials, e.g. enzymes, hormones, lymphokines
A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…
A61P 35/00
Antineoplastic agents

Family

Application61/747,067Us provisional application · filed 28 Dec 2012

Application14/655,982Division · filed 30 Dec 2013

Application15/934,526Division · filed 23 Mar 2018

Application16/874,826Division · filed 15 May 2020

Application18/048,270Division · filed 20 Oct 2022

Application19/574,885Division

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US 2016/0194398 A1Published application

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US 2026/0274947 A1This patent

From the US filing history. Foreign family members aren’t listed.