Antibodies To Cell Adhesion Molecule-Related/Down-Regulated By Oncogenes (CDON) And Uses Thereof
AssigneeInstitute for Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center
InventorsDenise C. Connolly, Alana M. O'Reilly, Tiffiney R. Hartman, Valerie L. Sodi
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Abstract
The present disclosure provides antibodies specifically binding N-terminal or C-terminal regions of Cell Adhesion Molecule-Related/Down-Regulated By Oncogenes (CDON) polypeptide, methods of making the same, and methods of treating humans having tumors by administering the antibody.
Claims19
1-32. (canceled)
A method of treating a human having a tumor comprising administering to the human in need thereof an antibody, or antigen-binding fragment thereof, that specifically binds Cell Adhesion Molecule-Related/Down-Regulated by Oncogenes (CDON) polypeptide, wherein the antibody, or antigen-binding fragment thereof, specifically binds:
- a) a polypeptide consisting of amino acids at positions corresponding to positions 1 to 200 according to SEQ ID NO:
- 1;
- or
- b) a polypeptide consisting of amino acids at positions corresponding to positions 1000 to 1287 according to SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.