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US 2026/0274941 A1Published application
Anti-tslp nanobodies and their applications
AssigneeShanghai Novamab Biopharmaceuticals Co., Ltd.
InventorsYakun WAN, Guanghui LI, Min ZHU, Junwei GAI, Xiaoning SHEN
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Abstract
An anti-TSLP nanobody and a use thereof are provided. A coding sequence encoding the anti-TSLP nanobody, corresponding expression vector and host cell capable of expressing the nanobody, and a method for producing the anti-TSLP nanobody are also provided. The anti-TSLP nanobody has a good TSLP/TSLPR blocking activity and is expressed using Pichia pastoris. Its fermenter expression yield can reach 17-23 g/L.
Claims19
An anti-TSLP nanobody, wherein the complementary determining regions (CDRs) of the VHH chain of the nanobody comprise CDR1 as shown in SEQ ID NO:
- 1, CDR2 as shown in SEQ ID NO:2, and CDR3 as shown in SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.