Bispecific binding molecule binding to vegf and ang2 and use thereof

A bispecific binding molecule binding to VEGF A and Ang2, comprising a first target-binding region specifically binding to VEGF A and a second target-binding region specifically binding to Ang2, wherein the second target-binding region is an anti-Ang2 VHH antibody comprising a HCDR1, a HCDR2, and a HCDR3, wherein:

• the HCDR1 comprises an amino acid sequence set forth in SEQ ID NO:
• 16;
• the HCDR2 comprises an amino acid sequence set forth in SEQ ID NO:
• 17 or 20;
• and
• the HCDR3 comprises an amino acid sequence set forth in SEQ ID NO:
• 18, and wherein the first target-binding region is
• wherein the anti-VEGF A scFv comprises a heavy chain variable region (VH) and a light chain variable region (VL), wherein the VL of the anti-VEGF A scFv comprises an LCDR1, an LCDR2, and an LCDR3, wherein the LCDR1 comprises an amino acid sequence set forth in SEQ ID NO:
• 31, the LCDR2 comprises an amino acid sequence set forth in SEQ ID NO:
• 32, and the LCDR3 comprises an amino acid sequence set forth in SEQ ID NO:
• 33;
• and the VH of the anti-VEGF A scFv comprises a HCDR1, a HCDR2, and a HCDR3, wherein the HCDR1 comprises an amino acid sequence set forth in SEQ ID NO:
• 35, the HCDR2 comprises an amino acid sequence set forth in SEQ ID NO:
• 36, and the HCDR3 comprises an amino acid sequence set forth in SEQ ID NO:
• 37.