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US 2026/0274935 A1Published application
Stable and soluble antibodies inhibiting vegf
AssigneeNovartis AG
InventorsLeonardo Borras, David Urech, Tea Gunde
Life of this patent
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Abstract
The present invention relates to soluble and stable anti-VEGF immunobinders comprising CDRs from rabbit monoclonal antibodies. Said antibodies are designed for the diagnosis and/or treatment of VEGF-mediated disorders. The hybridomas, nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
Claims21
-30. (canceled)
An anti-VEGF single-chain variable fragment (scFv), wherein the anti-VEGF scFv comprises a variable heavy chain (VH), and a variable light chain (VL) having the orientation:
- NH2-VL-linker-VH-COOH, wherein the VH comprises the sequence of SEQ ID NO:
- 164 and the VL comprises the sequence of SEQ ID NO:
- 87.
Dependencies are inferred from the claim text.